Fig. 3

Comparison of gene expression profiles of BRCA1 mutation carriers (n = 22) and non-carriers (n = 36). a Heat map showing unsupervised hierarchical clustering of 236 genes from the Nanostring Cancer Reference gene panel across BRCA1 mutation carriers and non-carriers. BRCA1 Mut: BRCA1 mutation carrier status and type; BRCA1 WT: BRCA1 wild-type gene status. b Unsupervised hierarchal clustering of gene expression profiles of freshly isolated blood leukocytes from BRCA1 mutation carriers and non-carriers, showing samples cluster by BRCA1 mutation status: 9/22 BRCA1 mutation carriers share similar gene expression profiles and cluster more closely together. Heat map shows the top differentially expressed genes and corresponding gene pathway enrichment analysis; green shows relatively under expressed genes and pathways, respectively; red shows relatively over-expressed genes and pathways, respectively