Table 1 Recurrent microRNA (miRNA) regulatory modules in PyMT breast cancer
From: MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice
Module | Number of genes | Number of miRNAs | Genes regulated during tumor progression |
|---|---|---|---|
ABC transporters | 22 | 69 | DNAH8 ABCC5 ABCA8A ABCB4 ABCA8B |
GPCR + cell surface receptor | 18 | 63 | ADGRB2 ADGRE5 ADGRG3 ADGRL1 ADGRL4 FZD9 L1CAM |
Fatty acid metabolism | 16 | 57 | ACSL1 ACADL ECH1 ECHS1 HPGD PPARA SNCA |
Cytokine-cytokine receptor + immune response | 50 | 100 | IL1B CX3CR1 PDGFRA GDF5 PDGFRB CXCL15 CXCL1 TNFRSF11A IL7R SBSPON BMP6 |
Epidermal growth factor | 32 | 87 | C1RA CCBE1 BMP1 NPNT NRG4 CD93 DLK1 ADGRE5 FAT4 WIF1 LAMA4 ADGRL4 TLL1 ADAM19 |
Cell adhesion molecules | 41 | 86 | JAM3 MPZ PTPRM MPZL1 CADM3 NLGN2 |
Calcium ion transport | 16 | 56 | ATP2C2 GJA4 CACHD1 TRPM6 CACNA1H RYR2 CYP27B1 CACNA1A RAMP2 JPH2 |
Calcium signaling + GPCR, rhodopsin-like domain | 40 | 80 | MYLK NOS1 PDGFRA AGTR1A PTGER3 HRH1 PDGFRB HTR7 PTGER1 HTR4 CACNA1H ADRB3 RYR2 SLC8A2 ADCY3 CACNA1A HTR2A LPAR2 S1PR1 TSPO |
Fibronectin domain | 49 | 101 | CHL1 PHYHIP SPEG EPHA2 MYLK PTPRM MYOM3 |
GTP-binding + RAS GTPase | 22 | 68 | RAB36 RAB3D RAB15 |
Angiogenesis | 18 | 52 | EPHA2 ANGPT2 JAM3 TNFAIP2 CCBE1 ENPEP FGF1 CYP1B1 EFNB2 S1PR1 TGFA RAMP2 MMP19 |
Axon guidance + semaphorin domain | 23 | 76 | SRGAP3 SEMA4G EPHA2 SEMA3A PLXNA1 EFNB1 SEMA3C DPYSL2 NFATC2 RGS3 L1CAM ABLIM2 LRRC4C SLIT3 PLXND1 ITGB3 |