Table 2 The most enriched functional categories among the 1000 genes most differentially expressed between LumA-R1 and LumA-R2 samples
Enrichment type | Term | Number of genes | P value |
|---|---|---|---|
Gene Ontology | Regulation of immune system process | 152 | 3.74e-50 |
Immune system process | 201 | 3.65e-47 | |
Regulation of leukocyte activation | 71 | 2.37e-28 | |
Regulation of multicellular organismal process | 183 | 2.89e-28 | |
Cell activation | 91 | 4.59e-28 | |
Regulation of response to external | 73 | 8.18e-27 | |
Regulation of biological quality | 218 | 1.82e-26 | |
Leukocyte activation | 67 | 1.95e-26 | |
Positive regulation of cell activation | 56 | 5.13e-24 | |
T cell activation | 45 | 4.93e-22 | |
Regulation of cell proliferation | 128 | 1.83e-21 | |
KEGG Pathways | Cytokine-cytokine receptor interaction | 56 | 4.76e-22 |
Hematopoietic cell lineage | 29 | 1.50e-17 | |
Cell adhesion molecules (CAMs) | 30 | 4.08e-13 | |
Primary immunodeficiency | 16 | 8.70e-13 | |
Chemokine signaling pathway | 31 | 1.14e-09 | |
Complement and coagulation cascades | 17 | 1.36e-08 | |
T cell receptor signaling pathway | 20 | 1.30e-07 | |
Allograft rejection | 11 | 6.44e-07 | |
Natural killer cell mediated cytotoxicity | 20 | 5.66e-06 | |
Pathways in cancer | 34 | 1.49e-05 | |
Wiki-Pathways | TCR signaling pathway | 10 | 1.55e-09 |
B cell receptor signaling pathway | 10 | 1.72e-06 | |
Focal adhesion | 11 | 5.88e-05 | |
Complement activation, classical pathway | 6 | 8.38e-05 | |
Chromosomal location | 11q23 | 18 | 1.84e-05 |
Xq23 | 8 | 4.99e-05 |