Fig. 2

Unsupervised analysis of luminal breast samples using RNA-Seq data. a Applying the K-Means algorithm on the 737 luminal samples using K = 2 splits the samples into two subgroups exhibiting better five-year prognostic value than the PAM50 luminal-A/luminal-B partition. b Five-year survival and recurrence for the two luminal breast cancer partitions. The partition into two RNA-Seq-based clusters outperforms PAM50 partition of the luminal samples in both survival and recurrence. P values were calculated using the log-rank test