Case-control study of mammographic density and breast cancer risk using processed digital mammograms

Breast Cancer Research

Table 3 Area of density, overall and for women age 50+ at mammogram

Quintile group	Frequency		Model 1^a		Model 2^b		Model 3^c
Quintile group	Case	Control	OR	95 % CI	OR	95 % CI	OR	95 % CI
Area of density, overall (297 cases and 1149 controls)
Q1: 11.95 or less	30	229	1.00	Ref	1.00	Ref	1.00	Ref
Q2: 11.96–19.09	45	230	1.44	0.86–2.42	1.45	0.86–2.43	1.43	0.85–2.40
Q3: 19.10–26.96	66	230	2.63	1.59–4.34	2.56	1.55–4.22	2.53	1.53–4.19
Q4: 26.97–37.78	68	230	2.86	1.74–4.69	2.88	1.75–4.75	2.85	1.73–4.69
Q5: 37.79+	88	230	3.53	2.18–5.71	3.45	2.12–5.60	3.48	2.14–5.65
Dense area^d			1.52	1.33–1.74	1.51	1.32–1.73	1.54	1.34–1.77
Area of density, women 50+ (288 cases and 1116 controls)
Q1: 11.80 or less	29	223	1.00	Ref	1.00	Ref	1.00	Ref
Q2: 11.81-18.71	44	223	1.48	0.88–2.51	1.49	0.88–2.52	1.47	0.87–2.50
Q3: 18.72-26.66	65	223	2.73	1.64–4.54	2.68	1.61–4.46	2.66	1.59–4.43
Q4: 26.67-37.40	66	223	2.96	1.79–4.91	2.96	1.79–4.92	2.93	1.76–4.87
Q5: 37.41+	84	224	3.54	2.17–5.79	3.49	2.13–5.71	3.51	2.15–5.76
Dense area^d			1.52	1.32–1.74	1.51	1.32–1.73	1.53	1.33–1.76

^aAdjusted for matching factors (age at FFDM, laterality, density batch number), BMI (continuous), and BMI (categorical)
^bAdjusted for matching factors, BMI (categorical and continuous), parity, first-degree family history, and hormone use
^cAdjusted for matching factors, BMI (categorical and continuous), parity, first-degree family history, hormone use, and breast area (continuous)
^dORs for cube root of dense area (continuous) per standard deviation unit

ISSN: 1465-542X