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Table 2 Genes dysregulated in FC-IBC02 cells by CEP-37440

From: The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Gene symbol

Gene description

Fold induction

p value

IFI27

Interferon, alpha-inducible protein 27

4.3

0.002

IFI6

Interferon, alpha-inducible protein 6

3.5

0.003

IFI35

Interferon-induced protein 35

2.4

0.013

IRF7

Interferon regulatory factor 7

2.1

0.036

CCL5

Chemokine ligand 5 (Rantes)

4.6

0.008

IL32

Interleukin 32

3.6

0.044

IL23A

Interleukin 23, alpha subunit P19

2.1

0.028

OAS2

2'-5'-oligoadenylate synthetase 2, 69/71 kDa

5.8

0.016

OAS3

2'-5'-oligoadenylate synthetase 3, 100 kDa

3.5

0.022

OAS1

2'-5'-oligoadenylate synthetase 1, 40/46 kDa

3.3

4.70E-04

MX1

MX dynamin-like GTPase 1

2.6

0.005

ISG15

ISG15 ubiquitin-like modifier

2.4

0.021

BIK

BCL2-interacting killer (apoptosis-inducing)

2.3

0.016

KDR

Kinase insert domain receptor

2.3

0.012

LAMP3

Lysosomal-associated membrane protein 3

3.6

0.013

CMPK2

Cytidine monophosphate kinase 2

3.0

0.03

KLHL38

Kelch-like family member 38

2.8

0.009

EFR3B

EFR3 homolog B

2.8

3.14E-04

KRT75

Keratin 75, type II

2.8

0.013

GNG11

Guanine nucleotide-binding protein, gamma 11

2.6

0.010

PLAUR

Plasminogen activator, urokinase receptor

2.6

0.024

HLA-B

Major histocompatibility complex, class I, B

2.4

2.50E-04

NPAS2

Neuronal PAS domain protein 2

2.4

0.031

HLA-B|HLA-C

Major histocompatibility complex,

2.3

2.38E-04

TAP1

Transporter 1, ATP-binding cassette, sub-family B

2.3

0.048

USP18|USP41

Ubiquitin specific peptidase 18/41

2.3

0.013

FNDC1

Fibronectin type III domain-containing 1

2.2

0.033

CD74

CD74 molecule

2.2

0.03

PSMB9

Proteasome subunit, beta type, 9

2.2

0.013

BHLHE41

Basic helix-loop-helix family, member E41

2.1

0.018

DLX2

Distal-less homeobox 2

2.1

0.025

DUSP5P

Dual specificity phosphatase 5 pseudogene 1

2.0

0.007

HLA-J|HLA-A

Major histocompatibility complex

2.0

0.007

OR2M1P|OR2M7

Olfactory receptors

−3.5

0.023

FMO2

Flavin containing monooxygenase 2

−2.6

0.026

RGS5

Regulator of G protein signaling 5

−2.6

0.036

TF

Transferrin

−2.2

0.031

CABP7

Calcium-binding protein 7

−2.2

0.021

LZTFL1

Leucine zipper transcription factor-like 1

−2.2

0.044

ATCAY

Ataxia, cerebellar, Cayman type

−2.1

0.038

EYA4

EYA transcriptional coactivator and phosphatase 4

−2.1

0.023

SMYD1

SET and MYND domain-containing 1

−2.0

0.041

TNMD

Tenomodulin

−2.0

0.007

  1. Cells were treated with 1000 nM CEP-37440 during 48 h and expression studies were performed
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Breast Cancer Research

ISSN: 1465-542X

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