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Table 2 Genes dysregulated in FC-IBC02 cells by CEP-37440

From: The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Gene symbol Gene description Fold induction p value
IFI27 Interferon, alpha-inducible protein 27 4.3 0.002
IFI6 Interferon, alpha-inducible protein 6 3.5 0.003
IFI35 Interferon-induced protein 35 2.4 0.013
IRF7 Interferon regulatory factor 7 2.1 0.036
CCL5 Chemokine ligand 5 (Rantes) 4.6 0.008
IL32 Interleukin 32 3.6 0.044
IL23A Interleukin 23, alpha subunit P19 2.1 0.028
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71 kDa 5.8 0.016
OAS3 2'-5'-oligoadenylate synthetase 3, 100 kDa 3.5 0.022
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46 kDa 3.3 4.70E-04
MX1 MX dynamin-like GTPase 1 2.6 0.005
ISG15 ISG15 ubiquitin-like modifier 2.4 0.021
BIK BCL2-interacting killer (apoptosis-inducing) 2.3 0.016
KDR Kinase insert domain receptor 2.3 0.012
LAMP3 Lysosomal-associated membrane protein 3 3.6 0.013
CMPK2 Cytidine monophosphate kinase 2 3.0 0.03
KLHL38 Kelch-like family member 38 2.8 0.009
EFR3B EFR3 homolog B 2.8 3.14E-04
KRT75 Keratin 75, type II 2.8 0.013
GNG11 Guanine nucleotide-binding protein, gamma 11 2.6 0.010
PLAUR Plasminogen activator, urokinase receptor 2.6 0.024
HLA-B Major histocompatibility complex, class I, B 2.4 2.50E-04
NPAS2 Neuronal PAS domain protein 2 2.4 0.031
HLA-B|HLA-C Major histocompatibility complex, 2.3 2.38E-04
TAP1 Transporter 1, ATP-binding cassette, sub-family B 2.3 0.048
USP18|USP41 Ubiquitin specific peptidase 18/41 2.3 0.013
FNDC1 Fibronectin type III domain-containing 1 2.2 0.033
CD74 CD74 molecule 2.2 0.03
PSMB9 Proteasome subunit, beta type, 9 2.2 0.013
BHLHE41 Basic helix-loop-helix family, member E41 2.1 0.018
DLX2 Distal-less homeobox 2 2.1 0.025
DUSP5P Dual specificity phosphatase 5 pseudogene 1 2.0 0.007
HLA-J|HLA-A Major histocompatibility complex 2.0 0.007
OR2M1P|OR2M7 Olfactory receptors −3.5 0.023
FMO2 Flavin containing monooxygenase 2 −2.6 0.026
RGS5 Regulator of G protein signaling 5 −2.6 0.036
TF Transferrin −2.2 0.031
CABP7 Calcium-binding protein 7 −2.2 0.021
LZTFL1 Leucine zipper transcription factor-like 1 −2.2 0.044
ATCAY Ataxia, cerebellar, Cayman type −2.1 0.038
EYA4 EYA transcriptional coactivator and phosphatase 4 −2.1 0.023
SMYD1 SET and MYND domain-containing 1 −2.0 0.041
TNMD Tenomodulin −2.0 0.007
  1. Cells were treated with 1000 nM CEP-37440 during 48 h and expression studies were performed