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Fig. 5 | Breast Cancer Research

Fig. 5

From: An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells

Fig. 5

DNA copy number and somatic mutation characteristics of breast cancer epitypes. Amount of copy number alterations [fraction of the genome altered (FGA)], percentage of breast tumors classified as complex arm-wise aberration index–positive (CAAI positive), and the number of amplifications per tumor stratified by epitype in the (a) discovery cohort and (b) validation cohort. c The fraction of tumors in each epitype with a mutation in PIK3CA, TP53, and CDH1 (left) and the total number of single base substitutions per tumor stratified by epitype (right) for 645 tumors in the validation cohort with exome sequence data. The number of samples is indicated on top for each epitype and cohort. Horizontal lines indicate median values across the cohort

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Breast Cancer Research

ISSN: 1465-542X

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