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Table 1 Clinico-pathological parameters of 213 human breast tumor specimens in relation to CREB3L1 mRNA expression

From: Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

 

CREB3L1 mRNA expressionb

 

Numbera

Low

High

P valuec

Spearman r

Parameter:

Age at diagnosis

 <68 years

109

45

64

0.000013

0.294

 ≥68 years

104

25

79

  

Tumor type

 Infiltrating ductile

170

66

104

0.000001

−0.325

 Infiltrating colloid

22

0

22

  

 Infiltrating lobular

20

2

18

  

 Infiltrating papillary

1

1

0

  

Tumor graded

 Grade 4

12

1

11

<0.000001

−0.342

 Grade 5

53

11

42

  

 Grade 6

48

11

37

  

 Grade 7

26

6

20

  

 Grade 8

63

32

31

  

 Grade 9

11

8

3

  

Estrogen receptor

 Negative

20

14

6

0.00064

0.232

 Positive

193

55

138

  

Progesterone receptor

 Negative

66

29

37

0.021

0.158

 Positive

147

40

107

  

Lymph node status

 Negative

69

23

46

0.120

−0.120

 Positive

101

38

63

  

 Unknown

43

8

35

  
  1. aOnly patients with primary breast cancer were included. bBased on quantitative real-time PCR results. cSignificance of Spearman rank correlation. Significant p values are marked in boldface. dGraded according to the Nottingham derivation of the Scarff Bloom Richardson system
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Breast Cancer Research

ISSN: 1465-542X

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