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Table 1 Clinico-pathological parameters of 213 human breast tumor specimens in relation to CREB3L1 mRNA expression

From: Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

  CREB3L1 mRNA expressionb
  Numbera Low High P valuec Spearman r
Parameter:
Age at diagnosis
 <68 years 109 45 64 0.000013 0.294
 ≥68 years 104 25 79   
Tumor type
 Infiltrating ductile 170 66 104 0.000001 −0.325
 Infiltrating colloid 22 0 22   
 Infiltrating lobular 20 2 18   
 Infiltrating papillary 1 1 0   
Tumor graded
 Grade 4 12 1 11 <0.000001 −0.342
 Grade 5 53 11 42   
 Grade 6 48 11 37   
 Grade 7 26 6 20   
 Grade 8 63 32 31   
 Grade 9 11 8 3   
Estrogen receptor
 Negative 20 14 6 0.00064 0.232
 Positive 193 55 138   
Progesterone receptor
 Negative 66 29 37 0.021 0.158
 Positive 147 40 107   
Lymph node status
 Negative 69 23 46 0.120 −0.120
 Positive 101 38 63   
 Unknown 43 8 35   
  1. aOnly patients with primary breast cancer were included. bBased on quantitative real-time PCR results. cSignificance of Spearman rank correlation. Significant p values are marked in boldface. dGraded according to the Nottingham derivation of the Scarff Bloom Richardson system