Fig. 4

MDA-MB-231 and SUM159 tumor models of xenograft mice treated with Cetuximab, Ixabepilone, and combination. Means of the percentage in tumor volume of control (intravenous (i.v.), PBS), Cetuximab (i.v., 4 mg/kg/weekly), Ixabepilone (intraperitoneal (i.p.), 10 mg/kg/weekly), or combination (Cetuximab, i.v + Ixabepilone, i.p (equivalent dose/weekly))-treated MDA-MB231 (a) or SUM159 (b) tumors in SCID/Beige mice were plotted as a function of time. Two-way analysis of variance with Bonferroni post-hoc test was used to determine significant differences among groups and p <0.05 was considered to be statistically significant