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Table 2 Univariate and multivariate analyses of variables associated with RFS in TNBC (N=101)

From: Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Variables Univariate analysis Multivariate analysis
HR 95 % CI P value HR 95 % CI P value
Age (<50 vs. >50) 1.45 0.765–2.727 0.2488    
Residual tumor size (>2.0 cm vs. <2.0 cm) 3.92 2.045–7.902 <0.0001* 2.59 1.302–5.396 0.0064*
Nodal status after NAC (positive vs. negative) 3.84 2.003–7.732 <0.0001* 2.97 1.509–6.178 0.0015*
Grade (III vs. I, II) 1.01 0.352–4.234 0.9903    
Basal-like vs. non basal-like 2.03 1.035–4.267 0.0389* 2.01 0.979–4.262 0.0532
Ki-67 LI (high vs. low) 1.35 0.716–2.562 0.3526    
Unstained TILs (low vs. high) 3.63 1.110–22.34 0.0301* 2.01 0.572–12.71 0.3101
CD8 (low vs. high) 3.92 2.016–8.105 <0.0001* 3.09 1.537–6.614 0.0013*
CD8 (as a continuous variable)a 1.01b 1.002–1.012 0.0021* 1.01b 1.001–1.011 0.0249*
FOXP3 (low vs. high) 1.30 0.689–2.456 0.4199    
FOXP3 (as a continuous variable)a 1.00b 0.997–1.008 0.3753    
CD8/FOXP3 (low vs. high) 2.43 1.239–5.097 0.0090* 2.07 1.029–4.436 0.0412*
CD8/FOXP3 (as a continuous variable)a 1.28b 1.085–1.616 0.0011* 1.14b 0.994–1.381 0.0631
  1. Multivariate cox regression analyses were performed for all potential variables that were significantly associated with survival in univariate analysis
  2. RFS recurrence free survival, HR hazard ratio, CI confidence interval, NAC neoadjuvant chemotherapy, LI labeling index, TIL tumor-infiltrating lymphocyte
  3. *The P value is significant
  4. aAnalyses were performed by the continuous variables
  5. bThe HRs of the continuous variables are shown as a unit ratio