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Table 2 Univariate and multivariate analyses of variables associated with RFS in TNBC (N=101)

From: Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Variables

Univariate analysis

Multivariate analysis

HR

95 % CI

P value

HR

95 % CI

P value

Age (<50 vs. >50)

1.45

0.765–2.727

0.2488

   

Residual tumor size (>2.0 cm vs. <2.0 cm)

3.92

2.045–7.902

<0.0001*

2.59

1.302–5.396

0.0064*

Nodal status after NAC (positive vs. negative)

3.84

2.003–7.732

<0.0001*

2.97

1.509–6.178

0.0015*

Grade (III vs. I, II)

1.01

0.352–4.234

0.9903

   

Basal-like vs. non basal-like

2.03

1.035–4.267

0.0389*

2.01

0.979–4.262

0.0532

Ki-67 LI (high vs. low)

1.35

0.716–2.562

0.3526

   

Unstained TILs (low vs. high)

3.63

1.110–22.34

0.0301*

2.01

0.572–12.71

0.3101

CD8 (low vs. high)

3.92

2.016–8.105

<0.0001*

3.09

1.537–6.614

0.0013*

CD8 (as a continuous variable)a

1.01b

1.002–1.012

0.0021*

1.01b

1.001–1.011

0.0249*

FOXP3 (low vs. high)

1.30

0.689–2.456

0.4199

   

FOXP3 (as a continuous variable)a

1.00b

0.997–1.008

0.3753

   

CD8/FOXP3 (low vs. high)

2.43

1.239–5.097

0.0090*

2.07

1.029–4.436

0.0412*

CD8/FOXP3 (as a continuous variable)a

1.28b

1.085–1.616

0.0011*

1.14b

0.994–1.381

0.0631

  1. Multivariate cox regression analyses were performed for all potential variables that were significantly associated with survival in univariate analysis
  2. RFS recurrence free survival, HR hazard ratio, CI confidence interval, NAC neoadjuvant chemotherapy, LI labeling index, TIL tumor-infiltrating lymphocyte
  3. *The P value is significant
  4. aAnalyses were performed by the continuous variables
  5. bThe HRs of the continuous variables are shown as a unit ratio