Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Table 1 Clinicopathological factors of triple-negative breast tumors with the status of CD8, FOXP3, the ratio of CD8/FOXP3 (N=101)

Factors	CD8			FOXP3			CD8/FOXP3
Factors	High	Low	P value	High	Low	P value	High	Low	P value
Age, years			0.838			0.415			0.682
<50	22	17		22	17		16	23
>50	33	29		29	33		29	33
Residual tumor size			0.005*			0.373			0.487
<2.0 cm	39	20		32	27		28	31
>2.0 cm	16	26		19	23		17	25
Nodal status after NAC			0.167			0.491			0.094
Negative	35	23		31	27		30	28
Positive	20	23		20	23		15	28
Residual cancer burden			0.052			0.908			0.013*
Class I	5	2		3	4		6	1
Class II	41	27		35	33		32	36
Class III	9	17		13	13		7	19
Histological grade			0.602			0.329			0.068
I, II	21	16		15	22		22	17
III	34	30		36	28		23	39
Neoadjuvant chemotherapy			0.726			0.319			0.136
Anthracycline and taxane-based	45	40		43	42		39	46
Anthracycline-based	9	5		8	6		4	10
Other	1	1		0	2		2	0
Basal-like type			0.314			0.546			0.417
Basal-like	30	30		32	28		29	31
Non basal-like	25	16		19	22		16	25
Ki-67 LI (cutoff: 50)			0.551			0.322			0.056
Low	26	25		23	28		28	23
High	29	21		28	22		17	33
CD8 (cutoff: 100)						0.0003*			0.010*
Low				14	32		14	32
High				37	18		31	24
FOXP3 (cutoff: 60)			0.0003*						0.0001*
Low	18	32					32	18
High	37	14					13	38
CD8/FOXP3 (cutoff: 1.6)			0.010*			0.0001*
Low	24	32		38	18
High	31	14		13	32

ISSN: 1465-542X