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Fig. 4 | Breast Cancer Research

Fig. 4

From: Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Fig. 4

The cases with low change rates of CD8+ TIL and CD8/FOXP3 ratio before and after neoadjuvant chemotherapy (NAC). The cutoffs of a high or low rate of changes were defined as near the median ratio as follows: CD8+ TIL, 1.4 and CD8/FOXP3 ratio, 1.8. Immunohistochemical images of tumor-infiltrating CD8+ (blue) and FOXP3+ (brown) lymphocytes in pretreatment biopsy specimens (a) and residual tumors after NAC (b) of the same patient (black arrow points to CD8+ lymphocytes, and red arrow points to FOXP3+ lymphocytes). c Changing levels of CD8+ TIL in each case; 20 of 40 cases experienced cancer recurrence and 14 patients died. d Changing levels of CD8/FOXP3 ratio in each case; 21 of 41 cases experienced cancer recurrence, and 16 patients died

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Breast Cancer Research

ISSN: 1465-542X

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