Table 5 Odds ratios per standard deviation increase in the log-transformed LIBRA and Quantra density measures (per-category in the ordinal BI-RADS density measure) adjusted for both BMI and the Gail risk factors (i.e., age at menarche, parity, family history, age, race and number of prior biopsies), P values, and discriminatory capacity (AUC) of the continuous and categorical BI-RADS breast density estimates

LIBRA: absolute dense area, cm²

2.57

<0.001

0.85^a

1

4.12

7.92

12.22

(Continuous)

(1.86–3.56)

(0.81–0.90)

(N/A - reference)

(2.54–6.71)

(3.9–16.19)

(5.18–28.98)

LIBRA: area percent density, PD %

2.64

<0.001

0.85^a

1

3.35

6.39

10.88

(Continuous)

(1.79–3.89)

(0.81–0.90)

(N/A - reference)

(2.07–5.44)

(3.04–13.41)

(4.18–28.21)

Quantra: absolute dense volume, cm³

1.96

<0.001

0.82

1

2.3

3.74

5.32

(Continuous)

(1.44–2.67)

(0.77–0.86)

(N/A - reference)

(1.57–3.36)

(2.04–6.86)

(2.47–11.46)

Quantra: volume percent density, VD %

2.24

<0.001

0.83^a

1

2.84

4.66

6.68

(Continuous)

(1.56–3.21)

(0.78–0.87)

(N/A - reference)

(1.78–4.52)

(2.34–9.26)

(2.85–15.58)

Radiologist’s BI-RADS density (ordinal categories)

1.06 (0.69–1.63)

0.78

0.80 (0.75–0.85)

Predominantly fatty

Scattered fibroglandular densities

Heterogeneously dense

Extremely dense

1

1.06

1.12

1.19

(N/A - reference)

(0.69–1.63)

(0.48–2.66)

(0.33–4.33)