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Table 2 Ten SNPs with the lowest P values for association with percent mammographic density

From: A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

SNP SNP type Chr Gene, RefSeq Feature Percent densitya   Dense area, cm2a Non-dense area, cm2a
Betab (95 % CI) P P adj c Betab (95 % CI) P Betab (95 % CI) P
rs181042206 Imputed 15 5.2kb 3′ of CYP1A1   −0.10 (−0.16, −0.04) 0.0006 2.51 −0.10 (−0.18, −0.02) 0.01 0.14 (0.05, 0.23) 0.002
rs12258125 Genotyped 10 272kb 5′ of ANKRD30A   0.09 (0.04, 0.14) 0.0008 1.53 0.10 (0.03, 0.17) 0.004 −0.07 (−0.14, 0.00) 0.07
rs11616761 Genotyped 13 CDC16 Intronic 0.14 (0.05, 0.23) 0.0022 2.83 0.18 (0.06, 0.29) 0.004 −0.11 (−0.24, 0.02) 0.09
rs4632572 Genotyped 3 254kb 5′ of ALCAM   0.08 (0.03, 0.14) 0.0027 2.59 0.14 (0.07, 0.21) 0.0002 0.00 (−0.08, 0.08) 0.96
rs11896627 Genotyped 2 241kb 5′ of NCKAP5   −0.08 (−0.13, −0.03) 0.0032 2.49 −0.10 (−0.17, −0.03) 0.003 0.03 (−0.05, 0.10) 0.51
rs2446585 Genotyped 10 FRMD4A Intronic −0.07 (−0.12, −0.02) 0.0038 2.46 −0.08 (−0.15, −0.02) 0.01 0.07 (−0.01, 0.14) 0.07
rs273352 Genotyped 18 MAPRE2 Intronic −0.08 (−0.13, −0.02) 0.0058 3.22 −0.08 (−0.15, −0.01) 0.04 0.10 (0.02, 0.18) 0.01
rs477705 Genotyped 18 MAPRE2 Intronic −0.08 (−0.13, −0.02) 0.0058 2.82 −0.08 (−0.15, −0.01) 0.03 0.10 (0.02, 0.18) 0.01
rs10776775 Genotyped 1 LOC100287722 Intronic −0.07 (−0.12, −0.02) 0.0062 2.64 −0.09 (−0.15, −0.02) 0.009 0.01 (−0.06, 0.08) 0.78
rs2057469 Genotyped 9 RAB14 3′-UTR −0.07 (−0.12, −0.02) 0.0066 2.55 −0.08 (−0.15, −0.01) 0.02 0.08 (0.00, 0.16) 0.04
  1. aSquare-root-transformed. bAdjusted for study, reference age, case status, current use of menopausal hormone therapy (MHT), former use of MHT, body mass index, number of pregnancies and principal components. cAdjusted P value, calculated by multiplying P value by number of tests (here n = 3,868) and dividing by assigned rank. SNP single nucleotide polymorphism, Chr chromosome, UTR untranslated region