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Archived Comments for: Reduced proliferation in breast cancer cells contacting the neighboring adipocytes in human breast cancer tissues

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  1. Proliferation and adipocyte-breast cancer cell contact

    Sanjib Chaudhary, Institute of Life Sciences

    3 February 2016

    I have read with great interest the article published by Ryu et al where they have reported a reduced proliferation in breast cancer cells which are in contact with the neighbouring adipocytes. Herein the authors have reviewed 528 surgical specimens of breast cancer patients and assessed the relative ratio of tumor-adipose contact with association with clinico-pathological features.

    Firstly, figure. 1c indicated that the smaller and low-grade tumors show a higher degree of direct tumor-adipose contact which is in contradiction with the previously published report that showed to promote increased breast tumor progression and high tumor size [1-7], the phenomenon also observed in other cancers [8]. The adipocytes in contact with the tumor cells overexpress proteases such as matrix metalloproteinase-11, and proinflammatory cytokines (interleukin (IL)-6, IL-1β) as seen in breast tumor histological and in vitro co-culture studies, thus mediate invasiveness, migration and proliferation [7, 9, 10]. This phenomenon is also seen in other cancer cells [8]. Thus, it is still unclear if the smaller tumors and low grade tumors are a resultant of tumor-adipose contact?

    Secondly, figure 1a, d and e show that breast tumor can be spatially defined into- adipose and gland side, and measured the mitotic index (both ER positive and negative tumors). However, it is demonstrated that co-injection of murine 3T3-F442A pre-adipocytes and MCF7 cells in SCID mice show progressive tumor growth and with large clusters of breast cancers in contact with adipocytes [11] as also observed in ER negative breast cancer cells [10]. Therefore, the association of mitotic index of tumor cells with ER status of the breast cancer patients (Fig. 1e) may be obscured?


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    Competing interests

    No conflict of interests exist