Table 3 Case-case analysis between invasive breast cancer and breast cancer in situ
From: Genetic risk variants associated with in situ breast cancer
SNP | Gene | Allelesa | Invasive breast cancer | Breast cancer in situ | OR (95 % CI) | Ptrend | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
MM | Mm | mmb | MM | Mm | mmb | ||||||
rs11249433 | NOTCH2 | T | G | 2569 | 3884 | 1474 | 412 | 588 | 228 | 1.03 (0.94-1.13) | 4,87E-01 |
rs10931936 | CASP8 | G | T | 4470 | 3697 | 775 | 595 | 479 | 82 | 1.06 (0.96-1.18) | 2,50E-01 |
rs1045485 | CASP8 | G | G | 4570 | 1293 | 102 | 629 | 163 | 15 | 1.09 (0.92-1.28) | 3,23E-01 |
rs13387042 | Intergenic | A | G | 2432 | 3707 | 1750 | 369 | 590 | 258 | 0.95 (0.88-1.04) | 2,96E-01 |
rs4973768 | SLC4A7 | G | T | 1976 | 4013 | 1932 | 300 | 617 | 307 | 0.97 (0.89-1.06) | 4,86E-01 |
rs4415084c | Intergenic | G | T | 2559 | 3863 | 1437 | 384 | 620 | 218 | 0.99 (0.91-1.08) | 8,66E-01 |
rs10941679 | Intergenic | A | G | 4193 | 3143 | 605 | 610 | 478 | 88 | 0.99 (0.89-1.09) | 8,19E-01 |
rs10069690 | TERT | G | T | 4243 | 3076 | 549 | 665 | 467 | 87 | 1.01 (0.91-1.11) | 9,01E-01 |
rs889312 | MAP3K1 | A | G | 3848 | 3306 | 729 | 603 | 506 | 130 | 0.96 (0.87-1.06) | 4,01E-01 |
rs17530068 | Intergenic | T | G | 5171 | 3453 | 582 | 727 | 425 | 86 | 1.05 (0.95-1.17) | 3,16E-01 |
rs13437553 | Intergenic | T | G | 3582 | 2288 | 361 | 340 | 181 | 41 | 1.05 (0.90-1.22) | 5,60E-01 |
rs1917063d | Intergenic | G | T | 5433 | 3301 | 497 | 741 | 424 | 74 | 1.02 (0.92-1.13) | 7,26E-01 |
rs9344191e | Intergenic | T | G | 4972 | 3566 | 645 | 680 | 447 | 100 | 1.01 (0.92-1.12) | 8,36E-01 |
rs2180341f | RNF146 | A | G | 4623 | 2823 | 479 | 685 | 458 | 81 | 0.94 (0.85-1.04) | 2,35E-01 |
rs3757318 | Intergenic | G | A | 7679 | 1443 | 66 | 1019 | 197 | 8 | 1.01 (0.86-1.18) | 9,46E-01 |
rs9383938 | Intergenic | G | T | 7563 | 1568 | 104 | 1013 | 212 | 12 | 1.01 (0.87-1.17) | 8,87E-01 |
rs2046210 | Intergenic | G | T | 3207 | 3633 | 1069 | 501 | 565 | 163 | 1.00 (0.91-1.10) | 9,69E-01 |
rs13281615 | Intergenic | A | G | 2544 | 3773 | 1455 | 419 | 582 | 210 | 1.07 (0.98-1.17) | 1,46E-01 |
rs1562430 | Intergenic | T | G | 3392 | 4347 | 1496 | 419 | 595 | 222 | 0.93 (0.85-1.02) | 1,12E-01 |
rs1011970 | CDKN2BAS | G | T | 6327 | 2623 | 258 | 793 | 396 | 42 | 0.85 (0.76-0.96) | 6,50E-03 |
rs865686 | Intergenic | T | G | 3847 | 4247 | 1125 | 481 | 599 | 157 | 0.93 (0.85-1.02) | 1,47E-01 |
rs2380205 | Intergenic | G | T | 2961 | 4505 | 1742 | 402 | 597 | 239 | 0.99 (0.91-1.08) | 8,03E-01 |
rs10995190 | ZNF365 | G | A | 6818 | 2172 | 172 | 943 | 277 | 18 | 1.07 (0.94-1.22) | 3,28E-01 |
rs16917302 | ZNF365 | A | G | 7599 | 1574 | 86 | 1006 | 220 | 12 | 0.97 (0.84-1.13) | 7,02E-01 |
rs1250003g | ZMIZ1 | A | G | 3395 | 4394 | 1432 | 444 | 567 | 227 | 0.93 (0.85-1.02) | 1,20E-01 |
rs3750817 | FGFR2 | G | T | 3146 | 3615 | 1063 | 503 | 552 | 178 | 1.01 (0.92-1.10) | 8,82E-01 |
rs2981582 | FGFR2 | G | T | 2469 | 3868 | 1546 | 385 | 608 | 241 | 1.00 (0.91-1.09) | 9,66E-01 |
rs3817198 | LSP1 | T | G | 3657 | 3387 | 821 | 550 | 540 | 138 | 0.97 (0.88-1.06) | 4,67E-01 |
rs909116 | LSP1 | T | G | 2610 | 4586 | 2040 | 357 | 608 | 269 | 1.02 (0.94-1.12) | 6,31E-01 |
rs614367 | Intergenic | G | T | 5119 | 1937 | 226 | 548 | 188 | 19 | 1.14 (0.98-1.33) | 9,15E-02 |
rs999737h | RAD51L1 | G | T | 4829 | 2702 | 401 | 751 | 418 | 58 | 1.04 (0.93-1.15) | 5,22E-01 |
rs3803662 | TNRC9 | G | T | 3655 | 3328 | 797 | 572 | 514 | 116 | 1.02 (0.92-1.12) | 7,25E-01 |
rs2075555 | COL1A1 | G | A | 5851 | 1856 | 165 | 939 | 265 | 13 | 1.18 (1.03-1.35) | 1,41E-02 |
rs6504950 | COX11 | G | A | 4296 | 3104 | 547 | 653 | 499 | 85 | 0.97 (0.88-1.07) | 5,34E-01 |
rs12982178 | USHBP1 | T | G | 6028 | 2990 | 327 | 790 | 391 | 58 | 0.95 (0.86-1.06) | 4,04E-01 |
rs8170 | C19Orf62 | G | A | 6237 | 2816 | 290 | 816 | 372 | 50 | 0.96 (0.85-1.07) | 4,36E-01 |
rs2284378i | RALY | G | T | 4080 | 3624 | 899 | 504 | 455 | 107 | 1.01 (0.92-1.12) | 7,95E-01 |
rs4911414 | Intergenic | G | T | 4177 | 3954 | 1048 | 549 | 545 | 135 | 1.02 (0.93-1.11) | 7,34E-01 |
rs311499j | GMEB2 | G | T | 7987 | 1162 | 66 | 1049 | 169 | 14 | 0.87 (0.74-1.03) | 1,03E-01 |