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Table 1 Key NICE guideline recommendations relating to risk-based early detection and prevention strategies

From: Can the breast screening appointment be used to provide risk assessment and prevention advice?

Early detection and prevention strategies

Moderate risk Lifetime risk 17 % to 29 %

High risk Lifetime risk 30 % + 10-year risk 8 %+

Gene carriers and 30-50 % likelihood for TP53, BRCA1, or BRCA2

10-year risk 3 % to 7.9 % from age 40 to 49 years

Mammography

Annual from age 40 to 49

Annual from age 40 to 59

Annual from age 40 to 69 except TP53

Magnetic resonance imaging

N/A

N/A

Annual from age 30 to 49, 25 to 59 for TP53

Tamoxifen

Consider 5 years of 20 mg daily

Offer 5 years of 20 mg daily

Offer 5 years of 20 mg daily

Raloxifene (post-menopausal)

Consider 5 years of 60 mg daily

Offer 5 years of 60 mg daily

Offer 5 years of 60 mg daily

  1. N/A, not applicable; NICE, National Institute of Health and Care Excellence