Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures

Table 1 Correlation between rKi67 and various relative DOT parameters

Analysis of correlation with rKi67 %	rStO₂	rTHC	rHbO₂	rHb	rμ_s’
Pearson’s correlation coefficient	0.89	0.55	0.68	−0.33	0.44
P-value	0.001	0.126	0.044	0.393	0.24
Spearman’s correlation coefficient	0.88	0.40	0.48	−0.43	0.35
P-value	0.003	0.291	0.194	0.250	0.359

Relative tissue oxygen saturation (rStO₂) and relative oxyhemoglobin concentration (rHbO₂) were highly correlated with rKi67. Results with statistical significance (p-value <0.05) are shown in bold (n = 9). rTHC denotes relative total hemoglobin concentration, rHb denotes relative deoxyhemoglobin concentration, and rμ_s' denotes relative reduced-scattering coefficients

ISSN: 1465-542X