Fig. 4
a Relative deoxyhemoglobin concentration (rHb) versus Ki67 expression in breast cancer tissues. Lower rHb is observed in Ki67-positive cancer compared to Ki67-negative cancer (p-value 0.01, n = 3 for Ki67-positive and n = 15 for Ki67-negative cancer). Squares and circles in the box plots show the values for each individual subject. On each box, the central bar is the median, the edges of the box mark the 25th and 75th percentiles and the whiskers extend to the most extreme data points not considered outliers. b Correlation between mammary metabolic rate of oxygen (rMMR2) and Ki67 in cancer for a subset of the Ki67-negative group (n = 5), for whom diffuse correlation spectroscopy flow measurements were available. Dotted lines indicate the 95 % confidence interval of the mean of the linear fit