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Table 1 Recommended intakes of EPA + DHA by cohort and organization

From: Omega-3 fatty acids for breast cancer prevention and survivorship

Cohort Source Daily recommendation
General health   
 Adults US Department of Agriculture ≥250 mg
 Adults European Food Safety Agency ≥250 mg
 Adults World Health Organization: ≥250 mg
 Adults Academy of Nutrition and Dietetics ≥500 mg
 Adults without CHD American Heart Association 500 mg (fatty fish ≥ 2 times/week)
 Adults International Society for the Study of Fatty Acids and Lipids ≥500 mg
Pregnancy   
 Pregnant/lactating International Society for the Study of Fatty Acids and Lipids ≥500 mg (≥300 mg DHA)
 Pregnant/lactating European Food Safety Agency ≥250 mg (100 to 200 mg DHA)
Heart disease and inflammatory disorders  
 CHD American Heart Association 1 g
 Patients with high TG American Heart Association 2 to 4 g
Generally viewed as safe upper limit  
 Population US Food and Drug Administration ≤3 g EPA + DHA
 Population European Safety Authority 5 g EPA + DHA
  1. CHD, coronary heart disease; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; TG, triglyceride.