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Table 3 The most frequently mutated genes in each molecular subtype [17,18]

From: Molecular characterization and targeted therapeutic approaches in breast cancer

Luminal A Luminal B HER2-enriched Basal-like
PIK3CA 45% PIK3CA 29% TP53 72% TP53 80%
MAP3K1 13% TP53 29% PIK3CA 39% TTN 19%
GATA3 13% GATA3 13% MUC16 14% USH2A 11%
TP53 12% TTN 12% LRP1 8% FLG 7%
CDH1 9% RYR2 7% ERBB3 8% MUC16 7%
TTN 9% RELN 5% DNAH11 8% PIK3CA 7%
MLL3 7% FAT3 5% LRP2 8% MUC17 6%
MAP2K4 6% MLL3 5% TTN 8% DNAH7 5%
NCOR1 5% MUC16 5% ATP1A4 7% FAT3 5%
AKT1 4% KCNB2 4% KIAA1109 7% SYNE1 5%
PTEN 4% MAP3K1 4% CACNA1E 7% DST 5%
  1. HER2, human epidermal growth factor receptor 2.