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Figure 3 | Breast Cancer Research

Figure 3

From: Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles

Figure 3

Immunization of HER2/neu-transgenic mice with Hp91 in nanoparticles delayed tumor development and prolonged survival. At 2 months of age, mice were immunized with 5 μg HER2 peptide in PBS, 25 μg of Hp91 free peptide, or 25 μg Hp91 delivered in PLGA-NPs. After final immunization, mice were monitored twice a week for tumor growth and survival. (A) Percentages of tumor-free mice were calculated as cumulative number of mice with tumor and mice that were tumor free. (B) Mice were sacrificed once tumor masses exceeded 1.5 cm mean diameter. HER2, human epidermal growth factor receptor 2; PBS, phosphate-buffered saline; PLGA-NPs, poly(D,L-lactic-co-glycolic) acid nanoparticles.

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Breast Cancer Research

ISSN: 1465-542X

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