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Table 3 Significant association between TFPI single nucleotide polymorphisms (SNPs) and clinicopathological characteristics and molecular subtypes

From: Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF

Characteristic

SNP

Risk allele

Odds ratio

95% CI

P

False discovery rate

T status

      

T1

  

Reference

Reference

Reference

Reference

T2 to T3

rs10153820

A

3.14

1.44, 6.86

0.004

0.056

TN status (ER-/PR-/HER2-negative)

      

No

  

Reference

Reference

Reference

Reference

Yes

rs8176541a

G

2.62

1.11, 5.35

0.026

0.092

 

rs3213739a

G

2.58

1.34, 4.99

0.005

0.033

 

rs8176479a

C

3.10

1.24, 7.72

0.015

0.071

 

rs2192824a

T

2.44

1.39, 4.93

0.002

0.033

N status

      

Positive

  

Reference

Reference

Reference

Reference

Negative

rs10179730

G

3.34

1.42, 7.89

0.006

0.083

Basal tumor subtype

      

Non-basal

  

Reference

Reference

Reference

Reference

Basal

rs3213739a

G

2.23

1.15, 4.34

0.018

0.107

 

rs8176479a

C

2.79

1.12, 6.96

0.028

0.107

 

rs2192824a

T

2.41

1.24, 4.65

0.009

0.107

 

rs10187622a

C

5.20

1.17, 23.20

0.031

0.107

Luminal B tumor subtype

      

Non-luminal B

  

Reference

Reference

Reference

Reference

Luminal B

rs16829086a

T

2.09

1.03, 4.25

0.041

0.191

 

rs10179730a

G

3.53

1.47, 8.46

0.005

0.066

 

rs10187622a

T

2.73

1.24, 6.03

0.013

0.091

Normal-like tumor subtype

      

Non-normal-like

  

Reference

Reference

Reference

Reference

Normal-like

rs5940

T

22.17

4.43, 110.8

0.0002

0.003

  1. aSNPs representing a haplotype effect. SNPs are listed by ascending chromosome positions. TFPI, tissue factor pathway inhibitor; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor 2.