Breast Cancer Research

Table 2 TFPI and TF tumor mRNA expression across clinicopathological breast cancer subtypes

From: Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF

		mRNA expression (tumor)								Protein levels (plasma)
Characteristic	Groups	Total TFPI (α + β)	P	TFPIα	P	TFPIβ	P	TF	P	Total TFPI	P	Free TFPI	P	TF	P
T-status	T1	−0.146	0.054	−0.135	0.257	−0.084	0.201	−0.023	0.652	72.01	0.013	10.82	0.997	4.14	0.125
	T2-T3	0.085		0.018		0.060		0.054		65.02		10.82		4.66
Grade	G1-G2	−0.022	0.850	−0.005	0.424	−0.033	0.743	0.271	0.003	71.04	0.082	10.66	0.682	4.63	0.557
	G3	−0.045		−0.113		0.004		−0.229		66.12		10.97		4.14
N-status	Negative	−0.109	0.091	−0.136	0.127	−0.082	0.104	0.005	0.881	69.93	0.183	10.77	0.869	4.95	0.282
	Positive	0.104		0.078		0.110		0.032		66.00		10.90		4.14
ER status	Positive	−0.067	0.317	−0.082	0.557	−0.056	0.183	0.001	0.784	69.42	0.240	10.91	0.671	4.42	0.409
PR status	Negative	0.076		0.011		0.123		0.057		65.44		10.52		5.28
	Positive	−0.131	0.021	−0.145	0.075	−0.112	0.014	0.085	0.244	69.81	0.195	11.19	0.175	4.32	0.246
HER2-status	Negative	0.161		0.108		0.182		−0.127		65.92		10.08		5.04
	Negative	−0.072	0.054	−0.101	0.073	−0.041	0.154	0.004	0.731	68.45	0.893	10.68	0.287	4.47	0.428
	Positive	0.313		0.301		0.228		0.103		69.09		12.05		4.78
HR status	Yes	0.076	0.326	0.007	0.587	0.114	0.221	0.016	0.991	64.78	0.161	10.41	0.568	5.26	0.470
	No	−0.066		−0.080		−0.052		0.014		69.57		10.94		4.47
Triple-negative status	Yes	−0.051	0.886	−0.110	0.718	0.041	0.635	−0.158	0.326	63.21	0.072	10.06	0.345	5.23	0.969
	No	−0.029		−0.048		−0.027		0.055		69.73		10.99		4.57

Median values for TFPI and TF mRNA expression in tumors and protein levels in plasma according to clinically defined groups. Corresponding P-values (unadjusted) are shown. Significant P-values in bold. TFPI, tissue factor pathway inhibitor; TF, tissue factor; HER2, human epidermal growth factor receptor 2.Abbreviations: T, tumor; G, grade; N, node; ER, estrogen receptor; PR, progesterone receptor; HR, hormone receptor.

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ISSN: 1465-542X

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