| |
mRNA expression (tumor)
|
Protein levels (plasma)
|
|---|
|
Characteristic
|
Groups
|
Total TFPI (α + β)
|
P
|
TFPIα
|
P
|
TFPIβ
|
P
|
TF
|
P
|
Total TFPI
|
P
|
Free TFPI
|
P
|
TF
|
P
|
|---|
|
T-status
|
T1
|
−0.146
|
0.054
|
−0.135
|
0.257
|
−0.084
|
0.201
|
−0.023
|
0.652
|
72.01
|
0.013
|
10.82
|
0.997
|
4.14
|
0.125
|
| |
T2-T3
|
0.085
| |
0.018
| |
0.060
| |
0.054
| |
65.02
| |
10.82
| |
4.66
| |
|
Grade
|
G1-G2
|
−0.022
|
0.850
|
−0.005
|
0.424
|
−0.033
|
0.743
|
0.271
|
0.003
|
71.04
|
0.082
|
10.66
|
0.682
|
4.63
|
0.557
|
| |
G3
|
−0.045
| |
−0.113
| |
0.004
| |
−0.229
| |
66.12
| |
10.97
| |
4.14
| |
|
N-status
|
Negative
|
−0.109
|
0.091
|
−0.136
|
0.127
|
−0.082
|
0.104
|
0.005
|
0.881
|
69.93
|
0.183
|
10.77
|
0.869
|
4.95
|
0.282
|
| |
Positive
|
0.104
| |
0.078
| |
0.110
| |
0.032
| |
66.00
| |
10.90
| |
4.14
| |
|
ER status
|
Positive
|
−0.067
|
0.317
|
−0.082
|
0.557
|
−0.056
|
0.183
|
0.001
|
0.784
|
69.42
|
0.240
|
10.91
|
0.671
|
4.42
|
0.409
|
|
PR status
|
Negative
|
0.076
| |
0.011
| |
0.123
| |
0.057
| |
65.44
| |
10.52
| |
5.28
| |
| |
Positive
|
−0.131
|
0.021
|
−0.145
|
0.075
|
−0.112
|
0.014
|
0.085
|
0.244
|
69.81
|
0.195
|
11.19
|
0.175
|
4.32
|
0.246
|
|
HER2-status
|
Negative
|
0.161
| |
0.108
| |
0.182
| |
−0.127
| |
65.92
| |
10.08
| |
5.04
| |
| |
Negative
|
−0.072
|
0.054
|
−0.101
|
0.073
|
−0.041
|
0.154
|
0.004
|
0.731
|
68.45
|
0.893
|
10.68
|
0.287
|
4.47
|
0.428
|
| |
Positive
|
0.313
| |
0.301
| |
0.228
| |
0.103
| |
69.09
| |
12.05
| |
4.78
| |
|
HR status
|
Yes
|
0.076
|
0.326
|
0.007
|
0.587
|
0.114
|
0.221
|
0.016
|
0.991
|
64.78
|
0.161
|
10.41
|
0.568
|
5.26
|
0.470
|
| |
No
|
−0.066
| |
−0.080
| |
−0.052
| |
0.014
| |
69.57
| |
10.94
| |
4.47
| |
|
Triple-negative status
|
Yes
|
−0.051
|
0.886
|
−0.110
|
0.718
|
0.041
|
0.635
|
−0.158
|
0.326
|
63.21
|
0.072
|
10.06
|
0.345
|
5.23
|
0.969
|
| |
No
|
−0.029
| |
−0.048
| |
−0.027
| |
0.055
| |
69.73
| |
10.99
| |
4.57
| |
- Median values for TFPI and TF mRNA expression in tumors and protein levels in plasma according to clinically defined groups. Corresponding P-values (unadjusted) are shown. Significant P-values in bold. TFPI, tissue factor pathway inhibitor; TF, tissue factor; HER2, human epidermal growth factor receptor 2.Abbreviations: T, tumor; G, grade; N, node; ER, estrogen receptor; PR, progesterone receptor; HR, hormone receptor.
