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Table 2 TFPI and TF tumor mRNA expression across clinicopathological breast cancer subtypes

From: Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF

  mRNA expression (tumor) Protein levels (plasma)
Characteristic Groups Total TFPI (α + β) P TFPIα P TFPIβ P TF P Total TFPI P Free TFPI P TF P
T-status T1 −0.146 0.054 −0.135 0.257 −0.084 0.201 −0.023 0.652 72.01 0.013 10.82 0.997 4.14 0.125
  T2-T3 0.085   0.018   0.060   0.054   65.02   10.82   4.66  
Grade G1-G2 −0.022 0.850 −0.005 0.424 −0.033 0.743 0.271 0.003 71.04 0.082 10.66 0.682 4.63 0.557
  G3 −0.045   −0.113   0.004   −0.229   66.12   10.97   4.14  
N-status Negative −0.109 0.091 −0.136 0.127 −0.082 0.104 0.005 0.881 69.93 0.183 10.77 0.869 4.95 0.282
  Positive 0.104   0.078   0.110   0.032   66.00   10.90   4.14  
ER status Positive −0.067 0.317 −0.082 0.557 −0.056 0.183 0.001 0.784 69.42 0.240 10.91 0.671 4.42 0.409
PR status Negative 0.076   0.011   0.123   0.057   65.44   10.52   5.28  
  Positive −0.131 0.021 −0.145 0.075 −0.112 0.014 0.085 0.244 69.81 0.195 11.19 0.175 4.32 0.246
HER2-status Negative 0.161   0.108   0.182   −0.127   65.92   10.08   5.04  
  Negative −0.072 0.054 −0.101 0.073 −0.041 0.154 0.004 0.731 68.45 0.893 10.68 0.287 4.47 0.428
  Positive 0.313   0.301   0.228   0.103   69.09   12.05   4.78  
HR status Yes 0.076 0.326 0.007 0.587 0.114 0.221 0.016 0.991 64.78 0.161 10.41 0.568 5.26 0.470
  No −0.066   −0.080   −0.052   0.014   69.57   10.94   4.47  
Triple-negative status Yes −0.051 0.886 −0.110 0.718 0.041 0.635 −0.158 0.326 63.21 0.072 10.06 0.345 5.23 0.969
  No −0.029   −0.048   −0.027   0.055   69.73   10.99   4.57  
  1. Median values for TFPI and TF mRNA expression in tumors and protein levels in plasma according to clinically defined groups. Corresponding P-values (unadjusted) are shown. Significant P-values in bold. TFPI, tissue factor pathway inhibitor; TF, tissue factor; HER2, human epidermal growth factor receptor 2.Abbreviations: T, tumor; G, grade; N, node; ER, estrogen receptor; PR, progesterone receptor; HR, hormone receptor.
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