Table 1 Characteristics of cases and controls in the AMBER Consortium, by included study (BWHS, CBCS, WCHS)
BWHS | CBCS | WCHS | Total | |||||
|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
Characteristics of breast cancer cases | ||||||||
Total | 1,313 | 804 | 774 | 2,891 | ||||
ER+ | 862 (66) | 436 (54) | 550 (71) | 1,848 (64) | ||||
ER– | 451 (34) | 368 (46) | 224 (29) | 1,043 (36) | ||||
Triple negative | 155 (12) | 210 (26) | 129 (17) | 494 (17) | ||||
Age at diagnosis | ||||||||
< 40 years | 98 (8) | 129 (16) | 87 (11) | 324 (11) | ||||
40 to 49 years | 385 (29) | 262 (33) | 209 (27) | 856 (30) | ||||
50 to 59 years | 456 (35) | 190 (24) | 277 (36) | 923 (32) | ||||
≥ 60 years | 374 (29) | 223 (28) | 191 (25) | 788 (27) | ||||
Oral contraceptive use among cases and controls | ||||||||
Ever use | ||||||||
No | 525 (40) | 3,768 (45) | 392 (49) | 387 (49) | 374 (48) | 477 (49) | 1,291 (45) | 4,632 (46) |
Yes | 788 (60) | 4,522 (55) | 412 (51) | 398 (51) | 400 (52) | 492 (51) | 1,600 (55) | 5,412 (54) |
Recency of OC use | ||||||||
< 5 years ago | 182 (14) | 950 (11) | 68 (8) | 52 (7) | 64 (8) | 73 (8) | 314 (11) | 1,075 (11) |
5 to 9 years ago | 68 (5) | 464 (6) | 44 (5) | 32 (4) | 36 (5) | 48 (5) | 148 (5) | 544 (5) |
10 to 14 years ago | 77 (6) | 499 (6) | 53 (7) | 59 (8) | 39 (5) | 37 (4) | 169 (6) | 595 (6) |
15 to 19 years ago | 105 (8) | 620 (7) | 95 (12) | 85 (11) | 45 (6) | 52 (5) | 245 (8) | 757 (8) |
20 to 24 years ago | 108 (8) | 692 (8) | 90 (11) | 102 (13) | 47 (6) | 65 (7) | 245 (8) | 859 (9) |
25 to 29 years ago | 124 (9) | 653 (8) | 35 (4) | 46 (6) | 55 (7) | 79 (8) | 214 (7) | 778 (8) |
≥ 30 years ago | 124 (9) | 644 (8) | 24 (3) | 21 (3) | 108 (14) | 130 (13) | 256 (9) | 795 (8) |
Duration of OC use | ||||||||
< 5 years | 316 (24) | 1,934 (23) | 159 (20) | 174 (22) | 152 (20) | 207 (21) | 627 (22) | 2,315 (23) |
5 to 9 years | 235 (18) | 1,364 (17) | 125 (16) | 123 (16) | 121 (16) | 142 (15) | 481 (17) | 1,629 (16) |
10 to 14 years | 178 (14) | 874 (11) | 81 (11) | 61 (8) | 71 (9) | 75 (8) | 330 (11) | 1,010 (10) |
≥ 15 years | 59 (4) | 350 (4) | 47 (6) | 40 (5) | 56 (7) | 68 (7) | 162 (6) | 458 (5) |