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Table 9 List of negative prognostic microRNA signatures in breast cancer

From: Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

miRNAs associated with negative outcome
miRNA Case cohort Validation cohort Reference
Detection Cells of origin Number of samples Technique Number of samples
miR-122 Deep sequencing Heterogeneous BC 42 qRT-PCR 26 [57]
miR-27b-3p qRT-PCR TNBC 58 qRT-PCR 41 [113]
miR-21 qRT-PCR IDC 109 NR NR [115]
  qRT-PCR Heterogeneous BC 84 NR NR [102]
miR-210 Deep sequencing IDC 118 NR NR [75]
  Meta-analysis NR 699 Meta-analysis Meta-analysis [116]
  Meta-analysis NR 1,809 Meta-analysis Meta-analysis [117]
miR-9 miRNA microarray ER+ BC 16 qRT-PCR 52 [120]
miR-187 LNA miRCURY LN+ BC 117 LNA miR probe 470 [121]
miR-155 qRT-PCR Heterogeneous BC 88 NR NR [122]
  qRT-PCR Heterogeneous BC 231 NR NR [123]
  1. BC, breast cancer; ER, estrogen receptor; IDC, invasive ductal carcinoma; LN, lymph node; LNA, Locked Nucleic Acid; miRNA, microRNA; NR, not reported; qRT-PCR, quantitative real-time polymerase chain reaction; TNBC, triple-negative breast cancer.