Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

Table 9 List of negative prognostic microRNA signatures in breast cancer

miRNAs associated with negative outcome
miRNA	Case cohort			Validation cohort		Reference
miRNA	Detection	Cells of origin	Number of samples	Technique	Number of samples	Reference
miR-122	Deep sequencing	Heterogeneous BC	42	qRT-PCR	26	[57]
miR-27b-3p	qRT-PCR	TNBC	58	qRT-PCR	41	[113]
miR-21	qRT-PCR	IDC	109	NR	NR	[115]
	qRT-PCR	Heterogeneous BC	84	NR	NR	[102]
miR-210	Deep sequencing	IDC	118	NR	NR	[75]
	Meta-analysis	NR	699	Meta-analysis	Meta-analysis	[116]
	Meta-analysis	NR	1,809	Meta-analysis	Meta-analysis	[117]
miR-9	miRNA microarray	ER⁺ BC	16	qRT-PCR	52	[120]
miR-187	LNA miRCURY	LN⁺ BC	117	LNA miR probe	470	[121]
miR-155	qRT-PCR	Heterogeneous BC	88	NR	NR	[122]
	qRT-PCR	Heterogeneous BC	231	NR	NR	[123]

BC, breast cancer; ER, estrogen receptor; IDC, invasive ductal carcinoma; LN, lymph node; LNA, Locked Nucleic Acid; miRNA, microRNA; NR, not reported; qRT-PCR, quantitative real-time polymerase chain reaction; TNBC, triple-negative breast cancer.

ISSN: 1465-542X