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Table 8 List of positive prognostic microRNA signatures in breast cancer

From: Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

miRNAs associated with positive outcome
miRNA Case cohort Validation cohort Reference
Detection Cells of origin Number of samples Technique Number of samples
let-7b LNA-ISH Early invasive BC 1,432 qRT-PCR 40 [97]
  LNA-ISH Heterogeneous BC 80 NR NR [101]
miR-205 LNA-ISH Ductal BC 1,475 qRT-PCR 40 [97]
  qRT-PCR Heterogeneous BC 84 NR NR [102]
miR-375 Solexa deep sequencing Stage II-III BC 42 qRT-PCR 26 [57]
miR-30a miRNA microarray IDC 221 NR NR [104]
  qRT-PCR Heterogeneous BC 96 NR NR [108]
miR-342-5p miRNA microarray Heterogeneous BC 101 miRNA microarray 1,302 [109]
miR-497 qRT-PCR Heterogeneous BC 128 NR NR [111]
  qRT-PCR IDC 48 NR NR [110]
  1. BC, breast cancer; IDC, invasive ductal carcinoma; LNA-ISH, Locked Nucleic Acid-in situ hybridization; miRNA, microRNA; NR, not reported; qRT-PCR, quantitative real-time polymerase chain reaction.