Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

Table 8 List of positive prognostic microRNA signatures in breast cancer

miRNAs associated with positive outcome
miRNA	Case cohort			Validation cohort		Reference
miRNA	Detection	Cells of origin	Number of samples	Technique	Number of samples	Reference
let-7b	LNA-ISH	Early invasive BC	1,432	qRT-PCR	40	[97]
	LNA-ISH	Heterogeneous BC	80	NR	NR	[101]
miR-205	LNA-ISH	Ductal BC	1,475	qRT-PCR	40	[97]
	qRT-PCR	Heterogeneous BC	84	NR	NR	[102]
miR-375	Solexa deep sequencing	Stage II-III BC	42	qRT-PCR	26	[57]
miR-30a	miRNA microarray	IDC	221	NR	NR	[104]
	qRT-PCR	Heterogeneous BC	96	NR	NR	[108]
miR-342-5p	miRNA microarray	Heterogeneous BC	101	miRNA microarray	1,302	[109]
miR-497	qRT-PCR	Heterogeneous BC	128	NR	NR	[111]
	qRT-PCR	IDC	48	NR	NR	[110]

BC, breast cancer; IDC, invasive ductal carcinoma; LNA-ISH, Locked Nucleic Acid-in situ hybridization; miRNA, microRNA; NR, not reported; qRT-PCR, quantitative real-time polymerase chain reaction.

ISSN: 1465-542X