Table 4 List of major diagnostic microRNA signatures for the early diagnosis of breast cancer

miR-15a

Upregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-18a

Upregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-107

Upregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-425

Upregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-133a

Downregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-139-5p

Downregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-143

Downregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-145

Downregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-365

Downregulated

Serum

n = 48 (24)

n = 60 (51)

[62]

miR-155

Upregulated

Serum

n = 184 (75)

Meta-analysis (inclusion of 3 studies)

[63]

miR-1

Upregulated

Serum

n = 32 (22)

n = 132 (101)

[64]

miR-133a

Upregulated

Serum

n = 32 (22)

n = 132 (101)

[64]

miR-133b

Upregulated

Serum

n = 32 (22)

n = 132 (101)

[64]

miR-92a

Upregulated

Serum

n = 32 (22)

n = 132 (101)

[64]

miR-148b

Upregulated

Plasma

n = 127 (80)

n = 207 (80)

[65]

miR-376c

Upregulated

Plasma

n = 127 (80)

n = 207 (80)

[65]

miR-409-3p

Upregulated

Plasma

n = 127 (80)

n = 207 (80)

[65]

miR-801

Upregulated

Plasma

n = 127 (80)

n = 207 (80)

[65]

miR-16

Upregulated

Plasma & tissue

n = 15 (15)

n = 170 (100)^a

[66]

miR-21

Upregulated

Plasma & tissue

n = 15 (15)

n = 170 (100)^a

[66]

miR-451

Upregulated

Plasma & tissue

n = 15 (15)

n = 170 (100)^a

[66]

miR-145

Downregulated

Plasma & tissue

n = 15 (15)

n = 170 (100)^a

[66]

miR-18a

Overexpressed in cases compared to controls^b

Serum

n = 205 (205)

n = 5 (5)

[67]

miR-181a

Overexpressed in cases compared to controls^b

Serum

n = 205 (205)

n = 5 (5)

[67]

miR-222

Overexpressed in cases compared to controls^b

Serum

n = 205 (205)

n = 5 (5)

[67]