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Table 4 List of major diagnostic microRNA signatures for the early diagnosis of breast cancer

From: Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

miR signature Expression (BC vs normal) Sample type Number of samples: BC (normal) Validation Reference
miR-15a Upregulated Serum n = 48 (24) n = 60 (51) [62]
miR-18a Upregulated Serum n = 48 (24) n = 60 (51) [62]
miR-107 Upregulated Serum n = 48 (24) n = 60 (51) [62]
miR-425 Upregulated Serum n = 48 (24) n = 60 (51) [62]
miR-133a Downregulated Serum n = 48 (24) n = 60 (51) [62]
miR-139-5p Downregulated Serum n = 48 (24) n = 60 (51) [62]
miR-143 Downregulated Serum n = 48 (24) n = 60 (51) [62]
miR-145 Downregulated Serum n = 48 (24) n = 60 (51) [62]
miR-365 Downregulated Serum n = 48 (24) n = 60 (51) [62]
miR-155 Upregulated Serum n = 184 (75) Meta-analysis (inclusion of 3 studies) [63]
miR-1 Upregulated Serum n = 32 (22) n = 132 (101) [64]
miR-133a Upregulated Serum n = 32 (22) n = 132 (101) [64]
miR-133b Upregulated Serum n = 32 (22) n = 132 (101) [64]
miR-92a Upregulated Serum n = 32 (22) n = 132 (101) [64]
miR-148b Upregulated Plasma n = 127 (80) n = 207 (80) [65]
miR-376c Upregulated Plasma n = 127 (80) n = 207 (80) [65]
miR-409-3p Upregulated Plasma n = 127 (80) n = 207 (80) [65]
miR-801 Upregulated Plasma n = 127 (80) n = 207 (80) [65]
miR-16 Upregulated Plasma & tissue n = 15 (15) n = 170 (100)a [66]
miR-21 Upregulated Plasma & tissue n = 15 (15) n = 170 (100)a [66]
miR-451 Upregulated Plasma & tissue n = 15 (15) n = 170 (100)a [66]
miR-145 Downregulated Plasma & tissue n = 15 (15) n = 170 (100)a [66]
miR-18a Overexpressed in cases compared to controlsb Serum n = 205 (205) n = 5 (5) [67]
miR-181a Overexpressed in cases compared to controlsb Serum n = 205 (205) n = 5 (5) [67]
miR-222 Overexpressed in cases compared to controlsb Serum n = 205 (205) n = 5 (5) [67]
  1. Common microRNAs (miRNAs) are indicated in bold. amiRs only detected in plasma, not in tissue. bCases, women who developed breast cancer (BC); controls, women who stayed BC-free.