Table 2 Comparison of gene centering with subgroup-specific strategy on the external study breast cohorts with skewed distribution a
From: Molecular subtyping for clinically defined breast cancer subgroups
Prediction (%) | |||||||
|---|---|---|---|---|---|---|---|
Dataset | Feature | Gene-centering method | Basal-like | HER2-enriched | LumA | LumB | Normal-like |
Trondheim | ER-positive | Standard | 10 (20.8) | 8 (16.7) | 9 (18.8) | 12 (25.0) | 9 (18.8) |
(n = 48) | Subgroup-specific | 2 (4.2) | 4 (8.3) | 23 (47.9) | 16 (33.3) | 3 (6.2) | |
TNBC | Triple-negative | Standard | 28 (36.4) | 9 (11.7) | 19 (24.7) | 12 (15.6) | 9 (11.7) |
(n = 77) | Subgroup-specific | 63 (81.8) | 6 (7.8) | 3 (3.9) | 3 (3.9) | 2 (2.6) | |