Markers for the identification of late breast cancer recurrence

Breast Cancer Research

Table 2 Summary of multi-gene/molecular scores for the prediction of recurrence

Score	Abbreviation	Details	Reference
MammaPrint	MammaPrint	70 gene-based expression profile using DNA microarray. Fresh frozen material is used to perform analysis.	[20,21]
Genomic Grade Index	GGI	97 gene-based assay using DNA micro array. Fresh frozen material is used to perform the analysis.	[23,24]
Oncotype Dx Recurrence Score	RS	21 gene-based expression profile score using qRT-PCR (16 cancer genes, 5 housekeeping genes). FFPE blocks used to extract RNA.	[25]
Immunohistochemical Score 4	IHC4	Includes information on estrogen receptor (ER), progesterone receptor (PgR), Ki67, and HER2. Score developed on transATAC data. FFPE blocks used to extract RNA to perform IHC for ER, PgR, Ki67, and HER2.	[31]
Prosina Risk of Recurrence Score	ROR	50 gene-based expression profile score using qRT-PCR. FFPE blocks used to extract RNA to perform analysis on nCounter system.	[34]
Breast Cancer Index	BCI	Multi-gene assay using qRT-PCR. Combination of two biomarkers HOXB13/IL17BR (H/I) and molecular grade index (MGI). FFPE blocks used to extract RNA to perform analysis.	[38,53]
EndoPredict	EPclin	12 gene-based expression profile score using qRT-PCR (8 cancer genes, 4 housekeeping genes). FFPE blocks used to extract RNA to perform analysis.	[41]

ATAC, Arimidex, Tamoxifen, Alone or in Combination; FFPE, formalin-fixed paraffin-embedded; HER2, human epidermal growth factor; qRT-PCR, quantitative real-time polymerase chain reaction.

ISSN: 1465-542X