Figure 2

Deregulated microRNA expression profiles associated with aromatase inhibitor resistance. Dendogram of 45 micro RNA (miRNA) probe sets deregulated at the basal level in the Res-Let and Res-Ana cells as compared with the MCF-7aro cells in two independent cell cultures (replicates 1 and 2). Using the Cluster and TreeView software packages, the miRNAs were ordered according to their degree of similarity after hierarchical clustering of their expression profiles. Each column represents a cell line replicate, and each row represents a miRNA. Expression levels above the median are presented in red, and those below are shown in green. Red asterisks represent miRNAs previously described as associated with estrogen receptor (ER)/estrogen signaling, ER activity, breast cancer or endocrine resistance [16,42].