Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women

Table 5 Adjusted odds ratios for above-median absolute mammographic density (>32.4 cm ² ) and above-median percent mammographic density (>28.5%) by CYP19A1 single-nucleotide polymorphism and stratified by median body mass index (23.6 kg/m ² )

Mammographic density	Genotype	Total (n = 202)	BMI ≤23.6 ( n = 101)	BMI >23.6 ( n = 101)
		OR (95% CI)	OR (95% CI)	OR (95% CI)
rs749292
Absolute density	AA	1.0	1.0	1.0
	Aa	0.59 (0.29, 1.22)	0.23 (0.07, 0.75)	1.28 (0.45, 3.63)
	aa	0.86 (0.37, 1.98)	0.28 (0.08, 1.05)	2.21 (0.68, 7.15)
Percent density	AA	1.0	1.0	1.0
	Aa	0.57 (0.25, 1.30)	0.19 (0.05, 0.82)	1.41 (0.42,4.74)
	aa	0.64 (0.25, 1.64)	0.17 (0.03, 0.82)	1.85 (0.49,6.99)
rs7172156
Absolute density	AA	1.0	1.0	1.0
	Aa	0.76 (0.39, 1.48)	1.49 (0.56, 3.97)	0.35 (0.13, 0.94)
	aa	1.16 (0.47, 2.88)	5.45 (1.13, 26.3)	0.34 (0.09, 1.25)
Percent density	AA	1.0	1.0	1.0
	Aa	0.85 (0.40, 1.82)	1.91 (0.64, 5.68)	0.40 (0.13, 1.22)
	aa	1.40 (0.51, 3.82)	5.48 (0.92, 32.7)	0.45 (0.11, 1.87)

Multivariable logistic regression adjusted for age, body mass index (BMI) and parity and stratified by median BMI (23.6 g/m²). Major homozygous genotype AA, heterozygous genotype Aa and minor homozygous genotype aa. Absolute mammographic density with median 32.4 cm² as cutoff. Percent mammographic density with median 28.5% as cutoff. CI: Confidence interval; OR: Odds ratio.

ISSN: 1465-542X