Table 6 Comparison of clinical and pathological characteristics of post-CT immune cell clusters (Y and Z) in BC patients with residual tumor after NCT
Number = 71 | ||||||
|---|---|---|---|---|---|---|
Cluster Y | Cluster Z | P (χ 2) | ||||
Characteristic | Number | % | Number | % | ||
Menopausal status | Postmenopausal | 10 | 34.5 | 23 | 54.8 | 0.09 |
Premenopausal | 19 | 65.5 | 19 | 45.2 | ||
Tumor type | Ductal invasive | 27 | 93.1 | 40 | 95.2 | 0.70 |
Lobular invasive | 2 | 6.9 | 2 | 4.8 | ||
Others | 0 | 0.0 | 0 | 0.0 | ||
Grade 3 (pre-CT) | Grade 1-2 | 7 | 28.0 | 26 | 65.0 | 0.004 |
Grade 3 | 18 | 72.0 | 14 | 35.0 | ||
Grade 3 (residual tumor) | Grade 1-2 | 15 | 51.7 | 29 | 74.4 | 0.053 |
Grade 3 | 14 | 48.3 | 10 | 25.6 | ||
HER2 | HER2 negative | 22 | 78.6 | 35 | 83.3 | 0.61 |
HER2 positive | 6 | 21.4 | 7 | 16.7 | ||
Hormone-sensitivity | Negative | 12 | 42.9 | 7 | 16.7 | 0.016 |
Positive | 16 | 57.1 | 35 | 83.3 | ||
IHC subtype | HS | 12 | 42.9 | 31 | 73.8 | 0.033 |
HS-HER2+ | 4 | 14.3 | 4 | 9.5 | ||
HER2+ | 2 | 7.1 | 3 | 7.1 | ||
Triple negative | 10 | 35.7 | 4 | 9.5 | ||
cN2-3 (pre-CT) | cN0-1 | 19 | 65.5 | 32 | 76.2 | 0.32 |
cN2-3 | 10 | 34.5 | 10 | 23.8 | ||
ypN | ypN0 | 12 | 41.4 | 21 | 50.0 | 0.47 |
ypN+ | 17 | 58.6 | 21 | 50.0 | ||
ypN2-3 | ypN0-1 | 17 | 70.8 | 26 | 76.5 | 0.63 |
ypN2-3 | 7 | 29.2 | 8 | 23.5 | ||
cT3-4 (pre-CT) | cT1-2 | 12 | 41.4 | 20 | 47.6 | 0.60 |
cT3-4 | 17 | 58.6 | 22 | 52.4 | ||
ypT | ypT0/is | 0 | 0.0 | 0 | 0.0 | 0.43 |
ypT1 | 10 | 34.5 | 9 | 21.4 | ||
ypT2 | 12 | 41.4 | 19 | 45.2 | ||
ypT3 | 4 | 13.8 | 11 | 26.2 | ||
ypT4 | 3 | 10.3 | 2 | 4.8 | ||
ypTx | 0 | 0.0 | 1 | 2.4 | ||