Figure 7

Distinct genetic signatures of luminal breast cancer patients are associated with specific mutations of GATA3. (A-D): Mean and distribution of expression levels of indicated genes are shown. The basal WT group are BLBC patients with no GATA3 mutations; DBD and TAD are luminal breast cancer patients heterozygous for GATA3 mutations within the DBD (exons 5, 6) or TAD (intron 4, 5 or exon 3), respectively. T-test P-values of the differences between the DBD and TAD groups are presented at the right bottom corner of each graph. BLBC, basal-like breast cancer; DBD, DNA binding domain; GATA3, GATA binding protein 3; TAD, transactivation domain; WT, wild type.