Figure 2

Druggability of significantly mutated gene (SMG) in breast cancer. (a) Overlap between six sources that generated a list of 354 possible drug-gene interactions among 315 genes recurrently mutated in breast cancer patients and analyzed by DGIdb. One hundred and seventy-six drug-gene interactions were identified by DrugBank, 87 by MyCancerGenome, 77 by Therapeutic Target Database (TTD), 71 by Trends in the Exploitation of Novel Drug Targets (TEND), 49 by Targeted Agents in Lung Cancer (TALC), and 44 by the Pharmacogenetics Knowledge Base (PharmGKB). (b) Distribution of 315 genes in potentially druggable categories (from dGene) and the numbers of genes in these categories that are targeted by a known drug.