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Table 2 Distribution of metastatic sites after treatment failure stratified by pretreatment circulating tumor cell count a

From: Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination

  Overall,N(%) CTCs <5/7.5 ml,n(%) CTCs ≥5/7.5 ml,n(%) P-value
Lymph nodes/soft tissuesb 48 (9.8) 40 (13.2) 8 (4.2) 0.0009
Bonec 337 (68.5) 180 (59.4) 157 (83.1) <0.0001
Viscerad 344 (69.9) 199 (65.7) 145 (76.7) 0.0114
Braine 59 (12.0) 30 (9.9) 29 (15.3) 0.0865
  1. aTreatment failure was defined as first disease progression after the baseline CTC evaluation. bLymph nodes/chest soft tissue only. cBone with or without other sites. dVisceral organ (including brain) with or without other sites. eBrain with or without other sites.