Relationships between computer-extracted mammographic texture pattern features and BRCA1/2mutation status: a cross-sectional study

Gierach, Gretchen L; Li, Hui; Loud, Jennifer T; Greene, Mark H; Chow, Catherine K; Lan, Li; Prindiville, Sheila A; Eng-Wong, Jennifer; Soballe, Peter W; Giambartolomei, Claudia; Mai, Phuong L; Galbo, Claudia E; Nichols, Kathryn; Calzone, Kathleen A; Olopade, Olufunmilayo I; Gail, Mitchell H; Giger, Maryellen L

doi:10.1186/s13058-014-0424-8

Table 1 Baseline characteristics of BRCA1/2 mutation carriers and non-carriers according to the training and testing datasets

From: Relationships between computer-extracted mammographic texture pattern features and BRCA1/2mutation status: a cross-sectional study

	Training dataset (n = 177)					Testing dataset (n = 60)
Variable	Non-carriers (n = 70)		UnaffectedBRCA1/2carriers (n = 107)		P-value for mutation carriers versus non-carriers	Non-carriers (n = 30)		UnaffectedBRCA1/2carriers (n = 30)		P-value for mutation carriers versus non-carriers	P-value²	P-value³
	Mean (SD)	Range	Mean (SD)	Range	P-value fromt-test	Mean (SD)	Range	Mean (SD)	Range	P-value fromt-test	P-value fromt-test
Age, years	48.8 (9.6)	25, 79	37.7 (8.5)	22, 55	<0.0001	47.2 (10.1)	25, 74	37.8 (8.9)	25, 55	0.0003	0.44	0.95
Body mass index¹	26.2 (5.7)	18.0, 45.5	25.5 (5.4)	17.9, 48.2	0.41	27.3 (6.7)	18.3, 49.5	25.9 (5.9)	19.5, 40.0	0.37	0.38	0.74
Percent mammographic density, unadjusted	32.2 (15.2)	3.5, 76.3	37.6 (14.7)	2.8, 70.8	0.02 ⁴	30.7 (14.7)	2.0, 53.7	35.5 (14.2)	4.8, 68.4	0.21⁴	0.66	0.47
	Number	% ^*	Number	% ^*	P -value from chi square ⁵	Number	% ^*	Number	% ^*	P -value from chi square ⁵	P -value from chi square ⁵
White, non-Hispanic	63	90.0	107	100.0	0.001	25	83.3	30	100.0	0.05	0.35	1.00
College graduate	52	74.3	83	77.6	0.62	21	70.0	22	73.3	0.77	0.66	0.63
Ever smoked	17	24.3	35	32.7	0.23	13	43.3	8	26.7	0.18	0.06	0.53
Age at menarche, years					0.78					0.87	0.96	0.40
<12	10	14.5	13	12.3		5	16.7	6	20.0
12 to 13	42	60.9	70	66.0		18	60.0	16	53.3
≥14	17	24.6	23	21.7		7	23.3	8	26.7
Missing	1		1
Parous	52	74.3	61	57.0	0.02	24	80.0	13	43.3	0.004	0.54	0.18
Age at first birth, years					0.09					0.02	0.27	0.62
<30	36	51.4	41	38.3		19	63.3	10	33.3
≥30 or nulliparous	34	48.6	66	61.7		11	36.7	20	66.7
Ever used oral contraceptives	51	72.9	96	89.7	0.004	24	80.0	26	86.7	0.49	0.45	0.64
Menopausal status					<0.0001					0.08	0.59	0.83
Premenopausal	44	64.7	60	56.1		16	57.1	19	63.3
Postmenopausal, natural	4	5.9	6	5.6		4	14.3	2	6.7
Postmenopausal, surgical	9	13.2	40	37.4		4	14.3	9	30.0
Postmenopausal, unknown	11	16.2	1	0.9		4	14.3	0	0.0
Missing	2		0			2		0
Menopausal hormone therapy					0.97					0.31	0.95	0.30
Never	48	68.6	74	69.2		20	66.7	25	83.3
Former	10	14.3	16	15.0		5	16.7	2	6.7
Current	12	17.1	17	15.9		5	16.7	3	10.0
Breast biopsy prior to enrollment	21	30.0	26	24.3	0.40	5	16.7	7	23.3	0.52	0.16	0.91

*Missing values were excluded from percentage calculations. ¹Weight (kg)/height² (m²). ²P-value comparing non-carriers in the training set to those in the testing set. ³P-value comparing BRCA1/2 carriers in the training set to those in the testing set. ⁴As previously reported [14], age-adjustment attenuatated the mean differences in percent mammographic density between carriers and non-carriers (age-adjusted P-value: training dataset = 0.79; testing dataset = 0.87). ⁵P-value from chi square test or Fisher’s exact test when appropriate. P-values <0.05 are shown in bold font.

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