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Table 1 Baseline characteristics of BRCA1/2 mutation carriers and non-carriers according to the training and testing datasets

From: Relationships between computer-extracted mammographic texture pattern features and BRCA1/2mutation status: a cross-sectional study

  Training dataset (n = 177) Testing dataset (n = 60)   
Variable Non-carriers (n = 70) UnaffectedBRCA1/2carriers (n = 107) P-value for mutation carriers versus non-carriers Non-carriers (n = 30) UnaffectedBRCA1/2carriers (n = 30) P-value for mutation carriers versus non-carriers P-value2 P-value3
  Mean (SD) Range Mean (SD) Range P-value fromt-test Mean (SD) Range Mean (SD) Range P-value fromt-test P-value fromt-test
Age, years 48.8 (9.6) 25, 79 37.7 (8.5) 22, 55 <0.0001 47.2 (10.1) 25, 74 37.8 (8.9) 25, 55 0.0003 0.44 0.95
Body mass index1 26.2 (5.7) 18.0, 45.5 25.5 (5.4) 17.9, 48.2 0.41 27.3 (6.7) 18.3, 49.5 25.9 (5.9) 19.5, 40.0 0.37 0.38 0.74
Percent mammographic density, unadjusted 32.2 (15.2) 3.5, 76.3 37.6 (14.7) 2.8, 70.8 0.02 4 30.7 (14.7) 2.0, 53.7 35.5 (14.2) 4.8, 68.4 0.214 0.66 0.47
  Number % * Number % * P -value from chi square 5 Number % * Number % * P -value from chi square 5 P -value from chi square 5
White, non-Hispanic 63 90.0 107 100.0 0.001 25 83.3 30 100.0 0.05 0.35 1.00
College graduate 52 74.3 83 77.6 0.62 21 70.0 22 73.3 0.77 0.66 0.63
Ever smoked 17 24.3 35 32.7 0.23 13 43.3 8 26.7 0.18 0.06 0.53
Age at menarche, years      0.78      0.87 0.96 0.40
<12 10 14.5 13 12.3   5 16.7 6 20.0    
12 to 13 42 60.9 70 66.0   18 60.0 16 53.3    
≥14 17 24.6 23 21.7   7 23.3 8 26.7    
Missing 1   1          
Parous 52 74.3 61 57.0 0.02 24 80.0 13 43.3 0.004 0.54 0.18
Age at first birth, years      0.09      0.02 0.27 0.62
<30 36 51.4 41 38.3   19 63.3 10 33.3    
≥30 or nulliparous 34 48.6 66 61.7   11 36.7 20 66.7    
Ever used oral contraceptives 51 72.9 96 89.7 0.004 24 80.0 26 86.7 0.49 0.45 0.64
Menopausal status      <0.0001      0.08 0.59 0.83
Premenopausal 44 64.7 60 56.1   16 57.1 19 63.3    
Postmenopausal, natural 4 5.9 6 5.6   4 14.3 2 6.7    
Postmenopausal, surgical 9 13.2 40 37.4   4 14.3 9 30.0    
Postmenopausal, unknown 11 16.2 1 0.9   4 14.3 0 0.0    
Missing 2   0    2   0     
Menopausal hormone therapy      0.97      0.31 0.95 0.30
Never 48 68.6 74 69.2   20 66.7 25 83.3    
Former 10 14.3 16 15.0   5 16.7 2 6.7    
Current 12 17.1 17 15.9   5 16.7 3 10.0    
Breast biopsy prior to enrollment 21 30.0 26 24.3 0.40 5 16.7 7 23.3 0.52 0.16 0.91
  1. *Missing values were excluded from percentage calculations. 1Weight (kg)/height2 (m2). 2P-value comparing non-carriers in the training set to those in the testing set. 3P-value comparing BRCA1/2 carriers in the training set to those in the testing set. 4As previously reported [14], age-adjustment attenuatated the mean differences in percent mammographic density between carriers and non-carriers (age-adjusted P-value: training dataset = 0.79; testing dataset = 0.87). 5P-value from chi square test or Fisher’s exact test when appropriate. P-values <0.05 are shown in bold font.