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Table 1 Summary of associations between seven single-nucleotide polymorphisms at 6q25.1 and breast cancer risk a

From: Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population

SNP Position (hg18) Associated gene Location Alleleb Casesc(n= 1064) Controlsc(n = 1073) MAFd HWEe Additive modelf
OR (95% CI) P-value
rs9383935 151981541 CCDC170 3' UTR G/A 414/500/149 528/439/106 0.38/0.30 0.31 1.38 (1.20 to 1.57) 2.21 × 10-6
rs2046210 151990059 Intergenic - G/A 349/517/196 447/475/150 0.43/0.36 0.19 1.32 (1.16 to 1.50) 2.04 × 10-5
rs488133 152167137 ESR1 intron G/A 867/184/11 906/160/7 0.10/0.08 1.00 1.15 (0.93 to 1.43) 0.208
rs2228480 152461788 ESR1 Thr594Thr G/A 682/340/40 633/387/49 0.20/0.23 0.34 0.84 (0.72 to 0.98) 0.025
rs3798577 152462823 ESR1 3' UTR A/G 336/527/196 305/541/226 0.43/0.46 0.67 0.90 (0.79 to 1.02) 0.093
rs3798758 152463547 ESR1 3' UTR C/A 520/441/98 577/425/69 0.30/0.26 0.48 1.19 (1.04 to 1.37) 0.013
rs3798757 152465936 ESR1 3' UTR A/G 856/185/20 879/182/10 0.11/0.09 0.86 1.16 (0.95 to 1.43) 0.149
  1. aCI, Confidence interval; OR, Odds ratio; SNP, Single-nucleotide polymorphism. bMajor/minor allele. cMajor homozygote/heterozygote/rare homozygote between cases and controls. dMinor allele frequency (MAF) among cases/controls. e Hardy-Weinberg equilibrium (HWE) test among controls. fLogistic regression with adjustment for age, age at menarche and menopausal status.