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Figure 3 | Breast Cancer Research

Figure 3

From: PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors

Figure 3

Androgen receptor (AR) + triple-negative breast cancer (TNBC) cell lines are sensitive to PI3K inhibitors. Bar graphs show the 50% inhibitory concentration (EC50) for TNBC cell lines treated for 72 h with single-agent (A) pan PI3K inhibitors (GDC-0941 and (B) NVP-BKM-120) or dual PI3K/mTOR inhibitors (GDC-0980 and NVP-BEZ235). Black horizontal bars above graphs indicate cell lines in which the EC50 was not reached at maximal concentration. Colorbar below indicates primary human mammary epithelial cell (HMECs) (black), AR + cell lines (green) and cell lines with PIK3CA mutations (red) or PTEN loss (blue). Error bars represent SD for three independent infections and experiments.

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Breast Cancer Research

ISSN: 1465-542X

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