Archived Comments for:
Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer
A new way in the war against breast cancer, fortunately.
Sergio Stagnaro, Private. Researcher in Biophysical Semeiotics
11 January 2005
Sirs,
in a previous comment posted on this web site ( Stagnaro S., Genes and Cancer: a clinical view-point. The Oncological Terrain.) http://www.biomedcentral.com/1471-2105/5/21/comments#10454), I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subject involved by abnormalities of pschyco-neuro-endocrinological-immune system (= Oncological Terrain). As a matter of fact, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells alterations, according to the well-known concept of Tiscendorf’s “Angiobiotopie”, I completed with “Angiobiopathy” concept (1, 2). In a few words, all oncological cell-dependent events (control, regulation, duplication, a.s.o.), may happen only by means of singular changes in local structural and functional microcirculation, which notoriously supplies information-material-energy to related tissue cells (See my HONCode web site www.semeioticabiofisica.it and “particularly” the linked Microangiologia.it). In fact, now-a-days, thanks to Biophysical Semeiotics, we can fortunately evaluate clinically microcirculatory bed structure and function in a precise manner of both breast cancer and all other biological systems, including lymphnodes and bone-marrow, assessing clinically local vasomotility and vasomotion (1-6). Assessing precisely the type of microcirculatory activation of breast cancer as well as of lymphnodes and bone-marrow (type I, associated, physiological; type II, intermediate, partially dissociated, characteristic of “real oncological risk”, and finally type III, dissociated, indicating cancer onset) we can evaluate in a quantitative way the alterations of physiological relation between vasomotility (= chaotic deterministic oscillations of small arterioles and arterioles, according to Hammersen, on the one hand, and vasomotion (= chaotic deterministic oscillations of related capillary and post-capillary primary venules), since the intensity of such as dissociation is correlated with the seriousness of underlying oncological disorders. From the above briefly referred clinical, biophysical-semeiotic remarks, observed in a long bed-side experience, I consider this article an epoch-making paper, and hope that Pub-Med will index it for Medline, in the interest of the mankind.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro-Neri M., Moscatelli G. Stagnaro S., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. Arch. Sc. Med. 155, 125 ,1996
4) Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109 ,1997
5) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: valutazione clinica del picco precoce della secrezione insulinica di base e dopo stimolazione tiroidea, surrenalica, con glucagone endogeno e dopo attivazione del sistema renina-angiotesina circolante e tessutale – Acta Med. Medit. 13, 99, 1997
6) Stagnaro-Neri M., Stagnaro S., Deterministic chaotic biological system: the microcirculatoory bed. Theoretical and practical aspects. Gazz. Med. It. – Arch. Sc. Med. 153, 99, 1994
A new way in the war against breast cancer, fortunately.
11 January 2005
Sirs,
in a previous comment posted on this web site ( Stagnaro S., Genes and Cancer: a clinical view-point. The Oncological Terrain.) http://www.biomedcentral.com/1471-2105/5/21/comments#10454), I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subject involved by abnormalities of pschyco-neuro-endocrinological-immune system (= Oncological Terrain). As a matter of fact, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells alterations, according to the well-known concept of Tiscendorf’s “Angiobiotopie”, I completed with “Angiobiopathy” concept (1, 2). In a few words, all oncological cell-dependent events (control, regulation, duplication, a.s.o.), may happen only by means of singular changes in local structural and functional microcirculation, which notoriously supplies information-material-energy to related tissue cells (See my HONCode web site www.semeioticabiofisica.it and “particularly” the linked Microangiologia.it). In fact, now-a-days, thanks to Biophysical Semeiotics, we can fortunately evaluate clinically microcirculatory bed structure and function in a precise manner of both breast cancer and all other biological systems, including lymphnodes and bone-marrow, assessing clinically local vasomotility and vasomotion (1-6). Assessing precisely the type of microcirculatory activation of breast cancer as well as of lymphnodes and bone-marrow (type I, associated, physiological; type II, intermediate, partially dissociated, characteristic of “real oncological risk”, and finally type III, dissociated, indicating cancer onset) we can evaluate in a quantitative way the alterations of physiological relation between vasomotility (= chaotic deterministic oscillations of small arterioles and arterioles, according to Hammersen, on the one hand, and vasomotion (= chaotic deterministic oscillations of related capillary and post-capillary primary venules), since the intensity of such as dissociation is correlated with the seriousness of underlying oncological disorders. From the above briefly referred clinical, biophysical-semeiotic remarks, observed in a long bed-side experience, I consider this article an epoch-making paper, and hope that Pub-Med will index it for Medline, in the interest of the mankind.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro-Neri M., Moscatelli G. Stagnaro S., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. Arch. Sc. Med. 155, 125 ,1996
4) Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109 ,1997
5) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: valutazione clinica del picco precoce della secrezione insulinica di base e dopo stimolazione tiroidea, surrenalica, con glucagone endogeno e dopo attivazione del sistema renina-angiotesina circolante e tessutale – Acta Med. Medit. 13, 99, 1997
6) Stagnaro-Neri M., Stagnaro S., Deterministic chaotic biological system: the microcirculatoory bed. Theoretical and practical aspects. Gazz. Med. It. – Arch. Sc. Med. 153, 99, 1994
Competing interests
Not declared