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Figure 3 | Breast Cancer Research

Figure 3

From: High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

Figure 3

Representative immunohistochemical staining of serial sections of three tumors for phospho-Akt, focal adhesion kinase (FAK) and HER2. (A1)–(A3) HER2: tumors with strong HER2 staining intensity (DAKO score 3+) (A1), weak HER2 staining (DAKO score 1+) (A2) and missing HER2 staining (DAKO score 0) (A3). (B1)–(B3) Tumors showing strong HER2 immunostaining (A1) more frequently exhibited strong FAK immunostaining (B1), whereas tumors expressing weak or no HER2 immunostaining were more often associated with weak or no FAK immunostaining (B2, B3). (C1)–(C3) Phospho-Akt: the percentage of phospho-Akt positively stained tumor cells ranged from more than 80% (C1) to 45% (C2) or was lower than 45% (C3). Higher HER2 (A1) and FAK (B1) staining intensites are correlated with higher percentage of phospho-Akt positively stained tumor cells (C1, C2). Original magnification, × 200.

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Breast Cancer Research

ISSN: 1465-542X

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