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Table 1 RNAi directed against c-Myc significantly inhibits MCF-7 cell growth in nude mice

From: Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo

No. of cellsa

pSilencer

pSilencer–c-Myc

 

Tumor weight (mg)

Tumors

Injections

Latencyb (day)

Tumor weight (mg)

Tumors

Injections

Latencyb (day)

106

45–210

3

5

42–49

0

0

5

>56

2 × 106

145–2248

4

5

21–28

0

0

5

>35

  1. aNumber of cells transfected with the indicated plasmids that were injected subcutaneously, bilaterally into five nude mice.
  2. bThe time interval required for a palpable tumor to arise.