Characteristic | All eligible patients (n = 5862) | Study responders only (n = 4968) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Nonresponders (n = 894) | Responders (n = 4968) | P value | Women with breast implants (n = 1018) | Women without breast implants (n = 3950) | P value | |||||
n | % | n | % | n | % | n | % | |||
SEER region | ||||||||||
San Francisco–Oakland | 468 | 52.4 | 1853 | 37.3 | 0.0001 | 416 | 40.9 | 1437 | 36.4 | 0.0001 |
Seattle–Puget Sound | 190 | 21.3 | 1663 | 33.5 | 374 | 36.7 | 1078 | 27.3 | ||
Iowa | 236 | 26.4 | 1452 | 29.2 | 228 | 22.4 | 1435 | 36.3 | ||
Year of diagnosis | ||||||||||
1983 | 246 | 27.5 | 1102 | 22.2 | 0.0001 | 176 | 17.3 | 926 | 23.4 | 0.0003 |
1985 | 241 | 27.0 | 1152 | 23.2 | 244 | 24.0 | 908 | 23.0 | ||
1987 | 230 | 25.7 | 1405 | 28.3 | 319 | 31.3 | 1086 | 27.5 | ||
1989 | 177 | 19.8 | 1309 | 26.3 | 279 | 27.4 | 1030 | 26.1 | ||
Age at diagnosis | ||||||||||
< 35 years | 59 | 6.6 | 175 | 3.5 | 0.0001 | 88 | 8.6 | 87 | 2.2 | 0.0001 |
35–44 years | 231 | 25.8 | 919 | 18.4 | 334 | 32.8 | 585 | 14.8 | ||
45–54 years | 256 | 28.6 | 1545 | 31.1 | 370 | 36.4 | 1175 | 29.8 | ||
55–64 years | 348 | 38.9 | 2329 | 46.9 | 226 | 22.2 | 2103 | 53.2 | ||
Mean age at diagnosis (years) | 49.9 | - | 52.1 | - | 0.0001 | 46.7 | - | 53.4 | - | 0.0001 |
Race/ethnicity | ||||||||||
Non-Hispanic White | 670 | 74.9 | 4444 | 89.5 | 0.0001 | 959 | 94.2 | 3485 | 88.2 | 0.0001 |
Non-Hispanic Black | 78 | 8.7 | 150 | 3.0 | 13 | 1.3 | 137 | 3.5 | ||
Hispanic | 38 | 4.3 | 131 | 2.6 | 20 | 2.0 | 111 | 2.8 | ||
Asian/Pacific Islander | 86 | 9.6 | 179 | 3.6 | 16 | 1.6 | 163 | 4.1 | ||
Other/unknown | 22 | 2.5 | 64 | 1.3 | 10 | 1.0 | 54 | 1.4 | ||
Stage at diagnosis | ||||||||||
In situ | 78 | 8.7 | 567 | 11.4 | 0.04 | 199 | 19.6 | 368 | 9.3 | 0.0001 |
Localized | 562 | 62.9 | 3141 | 63.2 | 601 | 59.0 | 2540 | 64.3 | ||
Regional | 241 | 27.0 | 1209 | 24.3 | 211 | 20.7 | 998 | 25.3 | ||
Unstaged | 13 | 1.5 | 51 | 1.0 | 7 | 0.7 | 44 | 1.1 | ||
Histology | ||||||||||
Infiltrating ductal | 687 | 76.9 | 3638 | 73.2 | 0.04 | 695 | 68.3 | 2943 | 74.5 | 0.0001 |
Lobular | 44 | 4.9 | 364 | 7.3 | 106 | 10.4 | 258 | 6.5 | ||
Infiltrating ductal and lobular | 35 | 3.9 | 195 | 3.9 | 54 | 5.3 | 141 | 3.6 | ||
Not otherwise specified/other | 128 | 14.3 | 771 | 15.5 | 163 | 16.0 | 608 | 15.4 | ||
Grade | ||||||||||
Well differentiated | 17 | 1.9 | 150 | 3.0 | 0.02 | 29 | 2.9 | 121 | 3.1 | 0.91 |
Moderately differentiated | 128 | 14.3 | 712 | 14.3 | 137 | 13.5 | 575 | 14.6 | ||
Poorly differentiated | 144 | 16.1 | 824 | 6.6 | 169 | 16.6 | 655 | 16.6 | ||
Undifferentiated | 17 | 1.9 | 185 | 3.7 | 39 | 3.8 | 146 | 3.7 | ||
Unknown grade | 588 | 65.8 | 3097 | 62.3 | 644 | 63.3 | 2453 | 62.1 | ||
Number of primary tumors | ||||||||||
One primary only | 771 | 86.2 | 4001 | 80.5 | 0.0001 | 867 | 85.2 | 3134 | 79.3 | 0.0001 |
Two or more primaries | 123 | 13.8 | 967 | 19.5 | 151 | 14.8 | 816 | 20.7 | ||
Radiation therapy during first course of treatment | ||||||||||
No | 814 | 91.1 | 4626 | 93.1 | 0.03 | 969 | 95.2 | 3657 | 92.6 | 0.01 |
Yes | 80 | 9.0 | 333 | 6.7 | 48 | 4.7 | 285 | 7.2 | ||
Unknown | 0 | 0 | 9 | 0.2 | 1 | 0.1 | 8 | 0.2 | ||
Vital statusa | ||||||||||
Alive | 538 | 60.2 | 3696 | 74.4 | 0.0001 | 867 | 85.2 | 2828 | 71.6 | 0.0001 |
Dead | 356 | 39.8 | 1272 | 25.6 | 151 | 14.8 | 1122 | 28.4 |