Atm heterozygous deficiency enhances development of mammary carcinomas in p53heterozygous knockout mice

Breast Cancer Research

Table 1 Incidence of tumours developing spontaneously in (BALB/cHeA × MSM/Ms)F₁ female mice that were heterozygously deficient for p53 and/or Atm genes

Genotypes	p53 ^+/-		p53^+/+
	Atm ^+/- (n = 28)	Atm ^+/+ (n = 22)	Atm ^+/- (n = 11)	Atm ^+/+ (n = 25)
Mammary carcinoma	14 (50%)^a	7 (32%)	0 (0%)	0 (0%)
Lymphoma	3 (11%)	3 (14%)	2 (18%)	4 (16%)
Ovarian carcinoma	1 (4%)	1 (5%)	0 (0%)	1 (4%)
Osteosarcoma	1 (4%)	0(0%)	0 (0%)	0 (0%)
Hepatoma	1 (4%)	0(0%)	0 (0%)	0 (0%)
Number of mammary carcinomas/mouse^b	14/28 (0.50)	7/22 (0.32)	0/11 (0.00)	0/25 (0.00)

^aNumber of mice with tumours. ^bTotal number of mammary carconomas developing in mice with given genotypes/number of mice examined; numbers in parentheses are average numbers of tumours per mouse.

ISSN: 1465-542X