Table 2 Distribution of participating nuclear families according to mother's breast cancer status, mother's and father's carrier status of the CYP17 and CYP19 variant alleles, and number of affected and unaffected daughters
Number of nuclear families according to mother's breast cancer status and genotype | Number of nuclear families according to father's genotype | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Number of daughters affected/unaffected | Affected | Unaffected | Total | Total | |||||||
Carrier | Non-carrier | Unknown | Carrier | Non-carrier | Unknown | Carrier | Non-carrier | Unknown | |||
CYP17 | |||||||||||
1/0 | 3 | 0 | 19 | 17 | 12 | 29 | 80 | 12 | 2 | 66 | 80 |
1/1 | 5 | 2 | 38 | 16 | 6 | 85 | 152 | 19 | 4 | 129 | 152 |
1/2 | 0 | 0 | 2 | 4 | 0 | 14 | 20 | 4 | 2 | 14 | 20 |
1/3 | 0 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 0 | 3 | 3 |
2/0 | 2 | 0 | 3 | 1 | 1 | 9 | 16 | 0 | 0 | 16 | 16 |
2/1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 2 |
2+/2+ | 0 | 0 | 1 | 2 | 0 | 1 | 4 | 1 | 0 | 3 | 4 |
Total | 10 | 2 | 64 | 42 | 19 | 140 | 277 | 36 | 8 | 233 | 277 |
CYP19 > = 10 repeats | |||||||||||
1/0 | 4 | 0 | 17 | 14 | 13 | 29 | 77 | 7 | 4 | 66 | 77 |
1/1 | 5 | 1 | 40 | 12 | 9 | 88 | 155 | 10 | 6 | 139 | 155 |
1/2 | 1 | 0 | 1 | 5 | 1 | 14 | 22 | 5 | 2 | 15 | 22 |
1/3 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 2 |
2/0 | 1 | 0 | 4 | 1 | 1 | 9 | 16 | 1 | 0 | 15 | 16 |
2/1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 2 |
2+/2+ | 0 | 0 | 1 | 0 | 1 | 2 | 4 | 0 | 0 | 4 | 4 |
Total | 12 | 1 | 63 | 33 | 25 | 144 | 278 | 24 | 12 | 242 | 278 |
CYP19 = 11 repeats | |||||||||||
1/0 | 4 | 0 | 17 | 11 | 16 | 29 | 77 | 6 | 5 | 66 | 77 |
1/1 | 5 | 1 | 40 | 11 | 10 | 88 | 155 | 9 | 7 | 139 | 155 |
1/2 | 1 | 0 | 1 | 6 | 1 | 13 | 22 | 5 | 3 | 14 | 22 |
1/3 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 2 |
2/0 | 1 | 0 | 4 | 1 | 1 | 9 | 16 | 1 | 0 | 15 | 16 |
2/1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 2 |
2+/2+ | 0 | 0 | 1 | 0 | 1 | 2 | 4 | 0 | 0 | 4 | 4 |
Total | 12 | 1 | 63 | 30 | 29 | 143 | 278 | 22 | 15 | 241 | 278 |