Figure 1
From: Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture
MCF10A cells and MCF10AT cells in monoculture and in co-culture with fibroblasts. (a), (b) MCF10A cells and (c), (d) MCF10AT cells in monoculture initially form a lattice/scaffold arrangement (a, c). After several days of culture, spheroidal structures become more prominent (b, d). (e) MCF10AT cells in co-culture with fibroblasts form three-dimensional rounded structures. Similar structures are formed by MCF10A cells in co-culture with fibroblasts (phase contrast, 100 × magnification; scale bar, 200 μm).