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Table 2 Association of CHEK2 variants with breast cancer risk

From: Frequency of CHEK2 mutations in a population based, case–control study of breast cancer in young women

CHEK2 statusa

Cases (n = 506)

Controls (n = 459)

ORb

95% CI

 

n

%

n

%

  

1100del C

      

   Noncarrier

499

98.8

456

99.6

1.0

Reference

   Carrier

6

1.2

2

0.4

2.9

(0.6–14.6)

R145W

      

   Noncarrier

505

99.8

459

100.0

1.0

Reference

   Carrier

1

0.2

0

-

-

-

I175T

      

   Noncarrier

504

99.6

455

99.1

1.0

Reference

   Carrier

2

0.4

4

0.9

0.5

(0.1–2.6)

  1. aAll carriers are heterozygous. bAdjusted for age at reference and reference year. CI, confidence interval; OR, odds ratio.
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Breast Cancer Research

ISSN: 1465-542X

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