Figure 6
From: Proteotypic classification of spontaneous and transgenic mammary neoplasms
Adenosquamous carcinoma in a BALB/cJ mouse: squamous differentiation is commonly associated with the presence of keratohyalin (a, arrowhead) or trichohyalin (b, arrowhead) granules. Squamous differentiation is 'complete', with expression of markers of all layers of the epidermis (c-e). Individual cells and small clusters of cells fail to express, or express only weakly, any terminal differentiation marker (f-i, arrowheads), whereas myoepithelial differentiation is observed in the areas of squamous differentiation (f, i, arrows). Scale bars, 50 μm (a, b) and 80 μm (c-i).