Figure 2

ERRB2 and GRB7 co-expression in microarray profiling data from primary breast cancers. The log ratios or log intensity values were downloaded for the ERBB2 and GRB7 probes from each of four publicly available microarray profiling data sets of primary breast cancers. (a) Log₁₀ ratios generated using 60-mer oligonucleotide arrays for the 98 node-negative tumors (78 sporadic tumors and 20 BRCA1/BRCA2 mutant tumors) versus a pooled reference of all 78 sporadic breast cancer RNA from the van't Veer and colleagues data set [11]. (b) Log₂ ratios generated using cDNA microarrays for 115 breast cancers and seven nonmalignant breast samples versus a universal reference RNA (mixed human cell lines) from the Sørlie and colleagues data set [4]. (c) Log₂ ratios generated from cDNA microarrays for 99 unselected breast cancers versus a universal reference (mixed human cell lines) from the Sotiriou and colleagues data set [5]. (d) Log₁₀ intensity values generated using Affymetrix oligonucleotide arrays for 49 breast cancers from the West and colleagues data set [3].