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Table 3 Relationships between nuclear expression of p14ARF with nuclear p53 and Hdm2 in invasive breast cancers

From: p14ARF expression in invasive breast cancers and ductal carcinoma in situ– relationships to p53 and Hdm2

  Nuclear p14ARF MQS
   0 (n = 19) 1+ (n = 28) 2+ (n = 42)
Nuclear p53 MQS 0 (n = 59) 13 21 25
  1+ (n = 17) 2 5 10
  2+ (n = 13) 4 2 7
  Nuclear p14 ARF MQS
   0 (n = 16) 1+ (n = 31) 2+ (n = 41)
Nuclear Hdm2 MQS 0 (n = 48) 13 17 18
  1+ (n = 31) 2 10 19
  2+ (n = 9) 1 4 4
  Nuclear p53 MQS
   0 (n = 58) 1+ (n = 15) 2+ (n = 11)
Nuclear Hdm2 MQS 0 (n = 47) 35 6 6
  1+ (n = 34) 23 7 4
  2+ (n = 3) 0 2 1
  1. Tumour numbers scored (MQS 0–8) by immunohistochemistry for nuclear p14ARF are compared with those for nuclear p53; nuclear p14ARF with nuclear Hdm2; and nuclear p53 with nuclear Hdm2. Nuclear expression of p14ARF, Hdm2 and p53 is represented as negative (0) (MQS 0–2), weak/moderate (1+) (MQS 3–5) and strong (2+) (MQS 6–8). Tumour numbers reflect the combined assessment of protein pairs. Positivity for p14ARF, p53 and Hdm2 expression was defined as 1+/2+ (MQS ≥ 3).