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Table 3 Relationships between nuclear expression of p14ARF with nuclear p53 and Hdm2 in invasive breast cancers

From: p14ARF expression in invasive breast cancers and ductal carcinoma in situ– relationships to p53 and Hdm2

 

Nuclear p14ARF MQS

  

0 (n = 19)

1+ (n = 28)

2+ (n = 42)

Nuclear p53 MQS

0 (n = 59)

13

21

25

 

1+ (n = 17)

2

5

10

 

2+ (n = 13)

4

2

7

 

Nuclear p14 ARF MQS

  

0 (n = 16)

1+ (n = 31)

2+ (n = 41)

Nuclear Hdm2 MQS

0 (n = 48)

13

17

18

 

1+ (n = 31)

2

10

19

 

2+ (n = 9)

1

4

4

 

Nuclear p53 MQS

  

0 (n = 58)

1+ (n = 15)

2+ (n = 11)

Nuclear Hdm2 MQS

0 (n = 47)

35

6

6

 

1+ (n = 34)

23

7

4

 

2+ (n = 3)

0

2

1

  1. Tumour numbers scored (MQS 0–8) by immunohistochemistry for nuclear p14ARF are compared with those for nuclear p53; nuclear p14ARF with nuclear Hdm2; and nuclear p53 with nuclear Hdm2. Nuclear expression of p14ARF, Hdm2 and p53 is represented as negative (0) (MQS 0–2), weak/moderate (1+) (MQS 3–5) and strong (2+) (MQS 6–8). Tumour numbers reflect the combined assessment of protein pairs. Positivity for p14ARF, p53 and Hdm2 expression was defined as 1+/2+ (MQS ≥ 3).
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Breast Cancer Research

ISSN: 1465-542X

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